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Synthesis 1987; 1987(11): 1039-1042
DOI: 10.1055/s-1987-28166
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Enantiomerically Pure 2-Bromoalkyl Aryl Ketones

Graziano Castaldi* , Claudio Giordano
  • *"G. Zambon" Chemistry Research Institute, Zambon Group, S.p.A., via Cimabue 26/28, 20032 - Cormano (Milano), Italy
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Publication Date:
12 September 2002 (online)

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The non-conventional hydrolysis of mixtures of diastereoisomeric α-bromo acetals, available in high yields, high diastereomeric excesses, and in large amounts, allows the synthesis and the full characterization of enantiomerically pure (2S)- and (2R)-bromoalkyl aryl ketones. The developed methodology represents the first route to enantiomerically pure 2-bromoalkyl aryl ketones of (2R) and (2S) configurations.

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