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Synthesis 1987; 1987(11): 1007-1009
DOI: 10.1055/s-1987-28149
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Stereochemically Controlled Bakers'-Yeast-Mediated Reductions: Synthesis of (S)-(+)-1,2-Propanediol and (S)-(-)-1,3-Butanediol,1-Benzyl Ethers

Ada Manzocchi* , Alberto Fiecchi, Enzo Santaniello
  • *Dipartimento di Chimica e Biochimica Medica, Università di Milano, Via Saldini 50, I-20133, Milano, Italy
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Publication Date:
12 September 2002 (online)

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Benzyloxyketones 1a and b can be reduced by fermenting bakers yeast to the corresponding protected (S)-diols 2a and b in 76 and 52% yields, respectively (90 and >95% e.e., respectively, as (R)-(+)-MTPA esters).

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