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Synthesis 1987; 1987(9): 824-827
DOI: 10.1055/s-1987-28089
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A Facile Synthesis of 1,2,3,4-Tetrahydroisoquinolines Through Cyclization of O,N-Acetals

Akinori Kubo* , Naoki Saito, Nanko Kawakami, Yasuo Matsuyama, Teruyo Miwa
  • *Department of Organic Chemistry, Meiji College of Pharmacy, 1-35-23 Nozawa, Setagaya-ku, Tokyo 154, Japan
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Publication Date:
12 September 2002 (online)

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A mild and efficient method for the synthesis of 1,2,3, 4-tetrahydroisoquinolines by a modified Pictet-Spengler reaction involving Lewis acid-mediated cyclization of O,N-acetals is described.

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