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Synthesis 1987; 1987(8): 723-724
DOI: 10.1055/s-1987-28061
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Regiospecific Oxidation of Methyl Groups in Dimethylanisoles

Frank M. Hauser* , Suzanne R. Ellenberger
  • *Department of Chemical and Biological Sciences, Oregon Graduate Center, Beaverton, OR 97006, U. S. A.
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Publication Date:
12 September 2002 (online)

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Dimethylanisoles in which one of the methyl groups is meta and the other is ortho or para are regiospecifically oxidized in high yield to the corresponding ortho- and para-substituted aldehydes by copper (II) and peroxydisulfate. Subsequent oxidation of the aldehydes with sodium chlorite furnishes the corresponding acids in excellent yield.

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