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Synthesis 1987; 1987(8): 718-719
DOI: 10.1055/s-1987-28058
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Aqueous Fluoride as a Nucleophile in the Synthesis of 2-Fluorostearic Acid

Stefano A. Pogány* , Gaylen M. Zentner, Cheryl D. Ringeisen
  • *INTERx Research Corporation, Merck. Sharp & Dohme Research Laboratories, 2201 West 21st Street, Lawrence, KS 66046, U. S. A.
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Publication Date:
12 September 2002 (online)

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2-Fluorostearic acid can be prepared consistently in high yield (84%) via nucleophilic displacement of bromide from methyl 2-bromostearate using moist silver(I) fluoride in wet acetonitrile.

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