Download PDF
Synthesis 1987; 1987(4): 379-381
DOI: 10.1055/s-1987-27951
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Novel Ring Transformations of 4-Acylamino- and 4-Dimethylaminomethyleneamino-1H-1,5-benzodiazepine-3-carbonitriles to Pyrimidine-5-carbonitriles

Kaname Takagi* , Tomoji Aotsuka, Hikari Morita, Yoshihisa Okamoto
  • *Central Research Laboratories, Zeria Pharmaceutical Co., Konanmachi, Osato-gun, Saitama 360-01, Japan
Further Information

Publication History

Publication Date:
20 August 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Reaction of 4-acylamino-1H-1,5-benzodiazepine-3-carbonitriles 1 with methylamine gave 2-alkyl-4-(o-aminophenylimino)-1-methyl-1,4-dihydropyrimidine-5-carbonitriles 4. 4-Dimethylaminomethyleneamino-1H-1,5-benzodiazepine-3-carbonitrile 2 also underwent analogous ring transformation with methylamine and ammonia to give pyrimidine-5-carbonitriles 9 and 10. The pyrimidines so formed were converted to benzimidazoles 6 and 12.

      >