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Synthesis 1986; 1986(11): 944-946
DOI: 10.1055/s-1986-31832
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A Convenient Synthesis of 3-Substituted 8-Methoxy-and 6,8-Dimethoxyisocoumarins

Christopher N. Lewis* , Peter L. Spargo, James Staunton
  • *University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW U. K.
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Publication Date:
20 August 2002 (online)

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The reaction of N-methoxy-N-methylamides with the anion of ethyl 2-methoxy- , or 2,4-dimethoxy-6-methylbenzoate gives the corresponding ketones, which are cyclised to give the 3-substituted 8-methoxy- and 6,8-dimethoxy-isocoumarins in good overall yield.

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