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Synthesis 1986; 1986(10): 871-872
DOI: 10.1055/s-1986-31815
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Formation of 1-Nitrosopyrrolidine from the Reaction of Pyrrolidine with Nitromethane and Triethyl Orthoformate. A Warning

Engelbert Ciganek*
  • *Biomedical Products Department, E I. du Pont de Nemours & Co., Wilmington, DE 19898, USA
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Publication Date:
20 August 2002 (online)

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1-nitrosopyrrolidine is formed as a byproduct in 3% yield during the synthesis of 2-pyrrolidino-1-nitroethylene. Care should taken in view of the carcinogenicity of nitrosamines when using these procedures.

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