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Synthesis 1986; 1986(9): 755-757
DOI: 10.1055/s-1986-31765
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A Novel Synthesis of N-Substituted-3-carboethoxymethylphthalimidines

R. S. Mali* , Suresh N. Yeola
  • *Department of Chemistry, University of Poona, Pune 411 007, India
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Publication Date:
20 August 2002 (online)

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A novel synthesis of N-substituted-3-carboethoxymethylphthalimidines 5 is described from secondary benzamides. The benzamides 1 on lithiation with n-butyllithium followed by treatment with dimethylformamide furnish 3-hydroxyphthalimidines 2 in 74-84% yield. Phthalimidines 2 on reaction with phosphorane 3, provide phthalimidines 5 in 67-95% yield, via esters 4.

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