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Synthesis 1986; 1986(8): 670-672
DOI: 10.1055/s-1986-31744
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Lithiation of 2-Aminoquinoline Derivatives: Functionalization at the 3-Position

J. M. Jacquelin* , F. Marsais, A. Godard, G. Queguiner
  • *Laboratoire de Chimie Organique Hétérocyclique, INSA, INSCIR, BP 08, F-76130 Mont Saint Aignan, France
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Publication Date:
22 August 2002 (online)

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2-Pivaloylaminoquinoline (2) undergoes o-lithiation with n-butyllithium to give the intermediate lithio derivative 3. Reaction of 3 with various electrophiles affords 3-substituted 2-pivaloylaminoquinolines 4.

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