Download PDF
Synthesis 1986; 1986(7): 582-584
DOI: 10.1055/s-1986-31715
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Preparation of Chiral ß-Hydroxyketones by Aldol-type Condensation of Chiral p-Tolylsulfinylmethyl Ketones

Fernand Schneider* , Roland Simon
  • *Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. AG, CH-4002 Basel, Switzerland
Further Information

Publication History

Publication Date:
20 August 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Chiral ß-hydroxyketones 7 with fair e.e. were prepared by treating newly prepared optically pure p-tolylsulfinylmethyl ketones 4 with t-butyl-magnesium bromide and aldehydes 5 followed by desulfurization with aluminium amalgam.

      >