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Synthesis 1986; 1986(5): 395-397
DOI: 10.1055/s-1986-31649
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Reactions with Aziridines; 351. α-Aryl-γ-amidobutyric Acids (N-Protected α-Aryl-GABAs) by Amidoethylation of Dianions of α-Arylacetic Acids

Helmut Stamm* , Rainer Weiss
  • *Pharmazeutisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 364, D-6900 Heidelberg, Federal Republic of Germany
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Publication Date:
27 September 2002 (online)

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Disodium enediolates of substituted acetic acids react with N-acylaziridines to yield the novel α-substituted γ-amidobutyric acids provided that the acid carries an aryl substituent in the α-position.

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