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Synthesis 1986; 1986(3): 212-213
DOI: 10.1055/s-1986-31618
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A Short Route to 2-(6-Methoxycarbonylhexyl)-cyclopent-2-en-1-one

Carla Boga* , Diego Savoia, Claudio Trombini, Achille Umani-Ronchi
  • *Istituto Chimico "G. Ciamician", Università di Bologna, via Selmi 2, I-40126 Bologna, Italy
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Publication Date:
20 August 2002 (online)

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The prostaglandin intermediate 2-(6-methoxycarbonylhexyl)-cyclopent-2-en-1-one (5) has been prepared by a short synthetic sequence, consisting of the reaction of 2-(1,3-dioxolan-2-yl)-ethylmagnesium bromide (1) with methyl 9-chloro-9-oxononanoate (2), followed by cleavage of the dioxolane ring of 3 and base-induced cyclisation of 4.

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