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Synthesis 1986; 1986(2): 139-140
DOI: 10.1055/s-1986-31500
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An Efficient, One-Pot Synthesis of 3-Methyl-1,3-thiazolidines

Wataru Ando* , Toshikazu Takata, Liren Huang, Yoshiharu Tamura
  • *Department of Chemistry, The University of Tsukuba, Sakura, Ibaraki 305, Japan
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Publication Date:
20 August 2002 (online)

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3-Methyl 1,3-thiazolidines 3a-c can be prepared easily in good yields by the reaction of β-mercaptoamine derivatives 1a-c with formalin and formic acid in a one-pot operation. The same procedure is also suitable for the construction of the 3-methyl-tetrahydro-1,3-thiazine skeleton from γ-mercaptoamines as exemplified in the synthesis of 3d.

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