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Klin Monbl Augenheilkd 2018; 235(04): 459-460
DOI: 10.1055/s-0044-101824
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Georg Thieme Verlag KG Stuttgart · New York

Oral Mucosa as a Treatment Option in Perforating Scleral Necrosis after Proton Beam Radiation Therapy

Mundschleimhaut als Therapieoption bei perforierender skleraler Nekrose nach Protonenbestrahlung
Kaltrina Zahiti-Rashiti
Department of Ophthalmology, University Hospital Basel, University Basel, Basel, Switzerland
,
Peter Meyer
Department of Ophthalmology, University Hospital Basel, University Basel, Basel, Switzerland
,
David Goldblum
Department of Ophthalmology, University Hospital Basel, University Basel, Basel, Switzerland
› Author Affiliations
Further Information

Publication History

received 03 September 2017

accepted 22 January 2018

Publication Date:
18 April 2018 (online)

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Background

Scleral necrosis is a rare post-radiogenic complication with a mean onset between 32 and 70.4 months after radiotherapy [1]. Protrusion of a previously irradiated tumor mass after plaque therapy has already been described [2], but it is very rare after proton beam therapy. In plaque therapy, the largest radiation dose is applied on the sclera, whereas in proton beam radiotherapy, the main radiation dose reaches the intraocular tumor. There are different therapeutic options, such as scleral patch grafts [3], amniotic membrane grafts [4], or corneal grafts [5]. Oral mucosa grafts have been successfully used for eye lid reconstructions [6] as well as a cover in osteo-odonto-keratoprothesis [7]. As far as we know, an oral mucosa graft has not yet been used successfully in treating perforating scleral necrosis secondary to radiotherapy.

 

  • References

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