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Int J Sports Med 2017; 38(12): 942-948
DOI: 10.1055/s-0043-116669
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

A Genetic Marker Associated with De Quervain’s Tenosynovitis

Stuart K. Kim
1   Dept. of Dev. Bio., Stanford, Stanford University, United States
,
Marwa A. Ahmed
2   Dept. of Orthopedic Surgery, Stanford University, Stanford, United States
,
Andy L. Avins
3   Division of Research, Kaiser Permanente Northern California, Oakland, United States
,
John P. A. Ioannidis
4   Department of Medicine, Stanford University, Stanford, United States
› Author Affiliations
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Publication History



accepted after revision 02 July 2017

Publication Date:
06 October 2017 (online)

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Abstract

De Quervain’s tenosynovitis is a repetitive strain injury involving synovial inflammation of the tendons of the first extensor compartment of the wrist. It is relatively common in the general population, and is the most common radial-sided tendinopathy seen in athletes. Identifying a genetic marker associated with de Quervain’s tenosynovitis could provide a useful tool to help identify those individuals with an increased risk for injury. A genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health (RPGEH) including 4,129 cases and 98,374 controls. rs35360670 on chromosome 8 showed an association with de Quervain’s tenosynovitis at genome-wide significance (p=1.9×10−8; OR=1.46; 95% CI=1.38–1.59). This study is the first genome-wide screen for de Quervain's tenosynovitis and provides insights regarding its genetic etiology as well as a DNA marker with the potential to inform athletes and other high-risk individuals about their relative risk for injury.

Key words

genome-wide association study - de Quervain's tenosynovitis - genetic epidemiology - sports genetics
 

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