Geburtshilfe Frauenheilkd 2017; 77(07): 729-732
DOI: 10.1055/s-0043-105643
GebFra Magazin
Aktuell diskutiert
Georg Thieme Verlag KG Stuttgart · New York

Strahlentherapie nach brusterhaltenden OP: Teilbrustbestrahlung mit Multikatheter-Brachytherapie als Alternative

Vratislav Strnad
Further Information

Publication History

Publication Date:
17 July 2017 (online)

Die nach einer brusterhaltenden Operation notwendige wochenlange Ganzbrustbestrahlung, einhergehend mit unterschiedlich ausgeprägter Strahlenbelastung der Haut, Lunge und des Herzens, kann bei ausgewählten Patientinnen mit einem kleinen Mammakarzinom durch eine „akzelerierte“ also eine „beschleunigte“ Teilbrustbestrahlung auf 4 – 5 Tage verkürzt werden und führt zu einer deutlich minimierten Strahlenbelastung. Die Behandlung durch „Teilbrustbestrahlung mit Multikatheter-Brachytherapie“ hat in einer Studie vergleichbare Langzeitergebnisse mit weniger Spätnebenwirkungen erzielt als der bisherige Standard „Ganzbrustbestrahlung“ mit einer höheren Strahlendosis und längerer Gesamtbehandlungszeit. Die Wirksamkeit der Teilbrustbestrahlung mittels Brachytherapie ist nachgewiesen und kann allen infrage kommenden Patienten in der klinischen Routine angeboten werden.

 
  • Literatur

  • 1 Clarke M, Collins R, Darby S. et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 366: 2087-2106
  • 2 Ragaz J, Olivotto IA, Spinelli JJ et al. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst 2005; 97: 116-126
  • 3 Lee LJ, Harris JR. Innovations in radiation therapy (RT) for breast cancer. Breast 2009; 18 (Suppl. 03) S103-S111
  • 4 Darby SC, Ewertz M, Hall P. Ischemic heart disease after breast cancer radiotherapy. N Engl J Med 2013; 368: 2527
  • 5 Showalter SL, Grover S, Sharma S. et al. Factors influencing surgical and adjuvant therapy in stage I breast cancer: a SEER 18 database analysis. Ann Surg Oncol 2013; 20: 1287-1294
  • 6 Lettmaier S, Kreppner S, Lotter M. et al. Radiation exposure of the heart, lung and skin by radiation therapy for breast cancer: a dosimetric comparison between partial breast irradiation using multicatheter brachytherapy and whole breast teletherapy. Radiother Oncol 2011; 100: 189-194
  • 7 King TA, Bolton JS, Kuske RR. et al. Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is,1,2) breast cancer. Am J Surg 2000; 180: 299-304
  • 8 Vicini FA, Chen PY, Fraile M. et al. Low-dose-rate brachytherapy as the sole radiation modality in the management of patients with early-stage breast cancer treated with breast-conserving therapy: preliminary results of a pilot trial. Int J Radiat Oncol Biol Phys 1997; 38: 301-310
  • 9 Vaidya JS, Wenz F, Bulsara M. et al. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. Lancet 2014; 383: 603-613
  • 10 Khan AJ, Arthur D, Vicini F. et al. Six-year analysis of treatment-related toxicities in patients treated with accelerated partial breast irradiation on the American Society of Breast Surgeons MammoSite Breast Brachytherapy registry trial. Ann Surg Oncol 2012; 19: 1477-1483
  • 11 Offersen BV, Overgaard M, Kroman N. et al. Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: a systematic review. Radiother Oncol 2009; 90: 1-13
  • 12 Njeh CF, Saunders MW, Langton CM. Accelerated partial breast irradiation using external beam conformal radiation therapy: a review. Crit Rev Oncol Hematol 2012; 81: 1-20
  • 13 Veronesi U, Orecchia R, Maisonneuve P. et al. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol 2013; 14: 1269-1277
  • 14 Polgar C, Fodor J, Major T. et al. Breast-conserving therapy with partial or whole breast irradiation: Ten-year results of the Budapest randomized trial. Radiother Oncol 2013; 108: 197-202
  • 15 Olivotto IA, Whelan TJ, Parpia S. et al. Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy. J Clin Oncol 2013; 31: 4038-4045
  • 16 Dodwell DJ, Dyker K, Brown J. et al. A randomised study of whole-breast vs. tumour-bed irradiation after local excision and axillary dissection for early breast cancer. Clin Oncol (R Coll Radiol) 2005; 17: 618-622
  • 17 Rodriguez N, Sanz X, Dengra J. et al. Five-year outcomes, cosmesis, and toxicity with 3-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 2013; 87: 1051-1057
  • 18 Polgar C, Strnad V, Kovacs G. Partial-breast irradiation or whole-breast radiotherapy for early breast cancer: a meta-analysis of randomized trials. Strahlenther Onkol 2010; 186: 113-114
  • 19 Livi L, Meattini I, Marrazzo L. et al. Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial. Eur J Cancer 2015; 51: 451-463
  • 20 Kunkler IH, Williams LJ, Jack WJ. et al. Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial. Lancet Oncol 2015; 16: 266-273
  • 21 Hughes KS, Schnaper LA, Bellon JR. et al. Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol 2013; 31: 2382-2387
  • 22 Potter R, Gnant M, Kwasny W. et al. Lumpectomy plus tamoxifen or anastrozole with or without whole breast irradiation in women with favorable early breast cancer. Int J Radiat Oncol Biol Phys 2007; 68: 334-340
  • 23 Strnad V, Ott OJ, Hildebrandt G. et al. 5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial. Lancet 2016; 387: 229-238
  • 24 Polgar C, Ott OJ, Hildebrandt G. et al. Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5-year results of a randomised, controlled, phase 3 trial. Lancet Oncol 2017; 18: 259-268
  • 25 Ott OJ, Strnad V, Hildebrandt G. et al. GEC-ESTRO multicenter phase 3-trial: accelerated partial breast irradiation with interstitial multicatheter brachytherapy versus external beam whole breast irradiation: early toxicity and patient compliance. Radiother Oncol 2016; 120: 119-123
  • 26 Polgar C, Van Limbergen E, Potter R. et al. Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: recommendations of the Groupe Europeen de Curietherapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009). Radiother Oncol 2010; 94: 264-273
  • 27 Smith BD, Arthur DW, Buchholz TA. et al. Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). J Am Coll Surg 2009; 209: 269-277
  • 28 Deutsche Gesellschaft für Radioonkologie e.V.. Pressemitteilung vom 18. November 2015/DEGRO: Brustkrebs im Frühstadium – Extrem verkürzte Bestrahlungszeit mit gleich guten Ergebnissen. Online: https://idw-online.de/de/news641733 Stand: 10.03.2017