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Der Nuklearmediziner 2017; 40(02): 134-147
DOI: 10.1055/s-0043-105515
Entzündungsdiagnostik
© Georg Thieme Verlag KG Stuttgart · New York

Nuklearmedizinische Entzündungsdiagnostik: Update 2017

Die Rolle monoklonaler Antikörper und in vitro markierter Leukozyten in der nuklearmedizinischen EntzündungsdiagnostikNuclear Medicine Evaluation of Infective Disease: Update 2017The Role of Monoclonal Antibodies and In Vitro Labelled Leukocytes in Radionuclide Imaging of Infection
Velimir Ivančević
Radiologisch-Nuklearmedizinische Gemeinschaftspraxis Celle, Celle
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Publication History

Publication Date:
13 June 2017 (online)

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Zusammenfassung

Die Szintigrafie mit radioaktiv markierten Leukozyten und Antigranulozytenantikörpern bildet den Eckpfeiler der nuklearmedizinischen Diagnostik entzündlicher und infektiöser Erkrankungen. Obwohl sich die FDG-PET/CT in der Diagnostik entzündlicher Erkrankungen in immer mehr Indikationen etabliert, bleibt die Szintigrafie mit markierten Leukozyten und Antigranulozytenantikörpern – auch wegen eingeschränkter Verfügbarkeit der FDG – bei entzündlichen Erkrankungen, die mit hoher Wahrscheinlichkeit erregerbedingt sind, die nuklearmedizinische Bildgebung der Wahl. In dieser Übersichtsarbeit werden die Entwicklung und der derzeitige Stellenwert der Leukozyten- und Antigranulozytenantikörperszintigrafie bei den wichtigsten dafür geeigneten Fragestellungen beleuchtet. Abschließend wird auch der aktuelle Kenntnisstand zum Beitrag der Hybridbildgebung SPECT/CT in der Diagnostik entzündlicher Erkrankungen wiedergegeben.

Abstract

Scintigraphy with radioactively labelled leukocytes and antigranulocyte antibodies constitutes the cornerstone of radionuclide imaging of inflammatory and infectious diseases. Although FDG-PET/CT is establishing itself more and more in diagnosing inflammatory diseases, scintigraphy with labelled leukocytes and antigranulocyte antibodies remains – also because of reduced availability of FDG − the radionuclide imaging modality of choice in inflammatory diseases which are very likely caused by pathogens. In this review the advancement and present status of labelled-leukocyte and antigranulocyte-antibody scintigraphy in the most important suitable indications is examined. Finally, the current knowledge about the contribution of hybrid imaging SPECT/CT to diagnosing inflammatory diseases is reported.

Schlüsselwörter

Markierte Leukozyten - Antigranulozytenantikörper - Szintigrafie - Hybridbildgebung - Entzündung - Infektion

Key words

Labelled leukocytes - antigranulocyte antibodies - scintigraphy - radionuclide imaging - hybrid imaging - inflammation - infection
 

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