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Int J Sports Med 2017; 38(04): 270-277
DOI: 10.1055/s-0042-123044
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study

Andréia Cristiane Carrenho Queiroz
1   School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil
2   Federal University of Juiz de Fora, Minas Gerais, Brazil
,
Julio Cesar Silva Sousa Jr.
1   School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil
,
Natan Daniel Silva Jr.
1   School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil
,
Eleonora Tobaldini
3   Department of Biomedical and Clinical Sciences “L. Sacco”, Medicine and Physiopathology, L. Sacco Hospital, University of Milan, Milan, Italy
,
Katia Coelho Ortega
4   General Hospital, University of São Paulo, São Paulo, Brazil
,
Edilamar Menezes de Oliveira
1   School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil
,
Patricia Chakur Brum
1   School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil
,
Nicola Montano
3   Department of Biomedical and Clinical Sciences “L. Sacco”, Medicine and Physiopathology, L. Sacco Hospital, University of Milan, Milan, Italy
,
Decio Mion Jr.
4   General Hospital, University of São Paulo, São Paulo, Brazil
,
Taís Tinucci
1   School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil
,
Claudia Lucia de Moraes Forjaz
1   School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil
› Author Affiliations
Further Information

Publication History



accepted after revision 23 November 2016

Publication Date:
20 February 2017 (online)

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Abstract

To evaluate whether captopril (3×50 mg/day) potentiates post-resistance exercise hypotension (PREH) in hypertensives (HT), 12 HT men received captopril and placebo for 4 weeks each in a double-blinded, randomized-crossover design. On each therapy, subjects underwent 2 sessions: Control (C – rest) and Resistance Exercise (RE – 7 exercises, 3 sets to moderate fatigue, 50% of 1 RM –repetition maximum). Measurements were taken before and after 30–60 min (Post1) and 7 h (Post2), and ambulatory blood pressure (BP) was monitored for 24 h. There were no differences in PREH characteristics and mechanisms between the placebo and captopril periods. At Post1, systolic/diastolic BP decreased significantly and similarly after RE with both therapies (Placebo=−13±2/−9±1 mmHg vs. Captopril=−12±2/−10±1 mmHg, P<0.05). RE reduced cardiac output in some subjects and systemic vascular resistance in others. Heart rate and cardiac sympathetic modulation increased, while stroke volume and baroreflex sensitivity decreased after RE (Placebo: +13±2 bpm, +21±5 nu, −11±5 ml, −4±2 ms/mmHg; Captopril: +13±2 bpm, +35±4 nu, 17±5 ml, −3±1 ms/mmHg, P<0.05). At Post2, all variables returned to pre-intervention values. Ambulatory BP was similar between the sessions. Thus, captopril did not potentiate the magnitude and duration of PREH in HT men, and it did not influence PREH mechanisms.

Key word

hypertension - angiotensin I-converting enzyme inhibitor - blood pressure - autonomic modulation - strength exercise - placebo-controlled
 

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