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Horm Metab Res 2017; 49(04): 296-300
DOI: 10.1055/s-0042-118459
Review

PKA and Apicomplexan Parasite Diseases

M. Haidar
1   Cochin Institute, Inserm U1016, CNRS UMR8104, Paris, France
2   Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, France
,
G. Ramdani
1   Cochin Institute, Inserm U1016, CNRS UMR8104, Paris, France
2   Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, France
3   Departments of Medicine, University of California, San Diego, La Jolla, California, USA
,
E. J. Kennedy
4   Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, USA
,
G. Langsley
1   Cochin Institute, Inserm U1016, CNRS UMR8104, Paris, France
2   Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, France
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Abstract

The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide variety of cellular processes including metabolism, cell growth, gene expression and apoptosis. cAMP-dependent PKA signaling pathways play important roles during infection and virulence of various pathogens. Since fluxes in cAMP are involved in multiple intracellular functions, a variety of different pathological infectious processes can be affected by PKA signaling pathways. Here, we highlight some features of cAMP-PKA signaling that are relevant to Plasmodium falciparum-infection of erythrocytes and present an update on AKAP targeting of PKA in PGE2 signaling via EP4 in Theileria annulata-infection of leukocytes and discuss cAMP-PKA signling in Toxoplasma.

Key words

cAMP - red blood cells - leukocytes - Theileria - Plasmodium - Merozoites - gametocytes


Publication History

Received: 29 June 2016

Accepted: 28 September 2016

Article published online:
11 November 2016

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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