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J Pediatr Genet 2022; 11(01): 015-021
DOI: 10.1055/s-0040-1717108
Original Article

Erythrocyte Complement Receptor 1 Gene Polymorphisms and Neonatal Respiratory Distress Syndrome

Walaa Rabie
1   Department of Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
,
Ahmed Al-Taweel
1   Department of Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
,
Walaa A. Abuelhamd
2   Department of Pediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
,
Walaa Shahin
2   Department of Pediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
,
Marian Nazeer
1   Department of Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
,
Hany Aly 
3   Department of Neonatology, Cleveland Clinic Children's, Cleveland, Ohio, United States
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Abstract

To evaluate the role of erythrocyte complement receptor 1 (ECR1) gene in the predisposition to respiratory distress syndrome (RDS), we studied 50 infants with RDS and 50 controls. Real-time polymerase chain reaction allelic discrimination analysis of A3650G (rs2274567) and genotyping of the alleles (HindIII) were performed. Allele L of HindIII restricted single nucleotide polymorphism (SNP) associated with the severity of RDS. Duration of oxygen and ventilation in genotypes AA and AG of A3650G SNP was longer than genotype GG (17.6 ± 19.4 and 8.6 ± 4.5 days, p = 0.01) and (8.9 ± 11.9 and 3.9 ± 3.53 days, p = 0.03), respectively. A3650G and HINDIII digested gene polymorphisms of ECR1 may be of little importance for RDS.

Keywords

Ecr1 - polymorphism - RDS - A3650G SNP


Publication History

Received: 28 May 2020

Accepted: 20 August 2020

Article published online:
05 October 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
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