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J Neurol Surg A Cent Eur Neurosurg 2020; 81(05): 412-417
DOI: 10.1055/s-0040-1709167
Original Article

Reactive Thrombocytosis in Non-aneurysmal Subarachnoid Hemorrhage

Daniel Dubinski 
1   Department of Neurosurgery, Goethe University Hospital, Frankfurt, Germany
,
Sae-Yeon Won
1   Department of Neurosurgery, Goethe University Hospital, Frankfurt, Germany
,
Bedjan Behmanesh
1   Department of Neurosurgery, Goethe University Hospital, Frankfurt, Germany
,
Nina Brawanski
1   Department of Neurosurgery, Goethe University Hospital, Frankfurt, Germany
,
Volker Seifert
1   Department of Neurosurgery, Goethe University Hospital, Frankfurt, Germany
,
Christian Senft
1   Department of Neurosurgery, Goethe University Hospital, Frankfurt, Germany
,
Juergen Konczalla
1   Department of Neurosurgery, Goethe University Hospital, Frankfurt, Germany
› Author Affiliations Funding Daniel Dubinski is a recipient of an Else Kröner-Fresenius-Foundation clinical research fellowship.
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Abstract

Background The role of reactive thrombocytosis in non-aneurysmal subarachnoid hemorrhage (NA-SAH) is largely unexplored to date. Therefore, the impact of a quantitative thrombocyte dynamic in patients with NA-SAH and its clinical relevance were analyzed in the present study.

Methods In this retrospective analysis, 113 patients with nontraumatic and NA-SAH treated between 2003 and 2015 at our institution were included. World Federation of Neurosurgical Societies admission status, cerebral vasospasm, delayed infarction, hydrocephalus, need for ventriculoperitoneal (VP) shunt, and Fisher grade were analyzed for their association with reactive thrombocytosis.

Results Reactive thrombocytosis was not associated with hydrocephalus (p ≥ 0.05), need for VP shunt implantation (p ≥ 0.05), cerebral vasospasm (p ≥ 0.05), or delayed cerebral ischemia (p ≥ 0.05).

Conclusion Our study is the first to investigate the role of thrombocyte dynamics, reactive thrombocytosis, and the clinical course of NA-SAH patients. Our analysis showed no significant impact of thrombocyte count on NA-SAH sequelae.

Keywords

non-aneurysmal subarachnoid hemorrhage - stroke and blood coagulation - hemostasis - platelets


Publication History

Received: 31 March 2019

Accepted: 30 July 2019

Article published online:
21 May 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 

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