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Synthesis 2020; 52(14): 2038-2044
DOI: 10.1055/s-0040-1707472
DOI: 10.1055/s-0040-1707472
paper
Palladium-Catalyzed [3+2] Cycloaddition of Vinylaziridine and Indane-1,3-diones: Diastereo- and Enantioselective Access to Spiro-Pyrrolidines
Further Information
Publication History
Received: 07 January 2020
Accepted after revision: 24 March 2020
Publication Date:
07 April 2020 (online)
§ These authors contributed equally to the work
† Deceased
Abstract
A mild and efficient palladium-catalyzed [3+2] cycloaddition of vinylaziridine and indane-1,3-diones has been realized. The resulting spiro-pyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio- and diastereoselectivities.
Key words
palladium catalysis - asymmetric synthesis - aziridines - sprio-pyrrolidines - indane-1,3-dionesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707471.
- Supporting Information
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References
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