Facile Access to 3,4-Disubstituted 2H-Chromenes via Domino [4+2] Annulation

Abstract

A highly efficient synthetic route to polysubstituted 2H-chromenes was developed utilizing a domino O-alkylation/intramolecular Horner–Wadsworth–Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.

Key words

chemical space - 2H-chromenes - domino reaction - intramolecular reaction - Horner–Wadsworth–Emmons olefination - one-pot three-component reaction

Publication History

Received: 01 October 2020

Accepted after revision: 02 November 2020

Article published online:
19 November 2020

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