Am J Perinatol 2021; 38(04): 342-349
DOI: 10.1055/s-0039-1697586
Original Article

Obesity, Second Stage Duration, and Labor Outcomes in Nulliparous Women

1   Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
,
Nandini Raghuraman
1   Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
,
Molly J. Stout
1   Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
,
Methodius G. Tuuli
1   Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
2   Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana
,
George A. Macones
1   Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
,
Alison G. Cahill
1   Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
› Author Affiliations
Funding A.G.C. is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD061619, PI Cahill), which partially supported this work.

Abstract

Objective This study aimed to estimate second stage duration and its effects on labor outcomes in obese versus nonobese nulliparous women.

Study Design This was a secondary analysis of a cohort of nulliparous women who presented for labor at term and reached complete cervical dilation. Adjusted relative risks (aRR) were used to estimate the association between obesity and second stage characteristics, composite neonatal morbidity, and composite maternal morbidity. Effect modification of prolonged second stage on the association between obesity and morbidity was assessed by including an interaction term in the regression model.

Results Compared with nonobese, obese women were more likely to have a prolonged second stage (aRR: 1.48, 95% CI: 1.18–1.85 for ≥3 hours; aRR: 1.65, 95% CI: 1.18–2.30 for ≥4 hours). Obesity was associated with a higher rate of second stage cesarean (aRR: 1.78, 95% CI: 1.34–2.34) and cesarean delivery for fetal distress (aRR: 2.67, 95% CI: 1.18–3.58). Obesity was also associated with increased rates of neonatal (aRR: 1.38, 95% CI: 1.05–1.80), but not maternal morbidity (aRR: 1.06, 95% CI: 0.90–1.25). Neonatal morbidity risk was not modified by prolonged second stage.

Conclusion Obesity is associated with increased risk of neonatal morbidity, which is not modified by prolonged second stage of labor.



Publication History

Received: 31 March 2019

Accepted: 12 August 2019

Article published online:
28 September 2019

© 2019. Thieme. All rights reserved.

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  • References

  • 1 Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in obesity among adults in the United States, 2005 to 2014. JAMA 2016; 315 (21) 2284-2291
  • 2 Usha Kiran TS, Hemmadi S, Bethel J, Evans J. Outcome of pregnancy in a woman with an increased body mass index. BJOG 2005; 112 (06) 768-772
  • 3 Sebire NJ, Jolly M, Harris JP. et al. Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. Int J Obes Relat Metab Disord 2001; 25 (08) 1175-1182
  • 4 Lu GC, Rouse DJ, DuBard M, Cliver S, Kimberlin D, Hauth JC. The effect of the increasing prevalence of maternal obesity on perinatal morbidity. Am J Obstet Gynecol 2001; 185 (04) 845-849
  • 5 Heslehurst N, Simpson H, Ells LJ. et al. The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: a meta-analysis. Obes Rev 2008; 9 (06) 635-683
  • 6 Kominiarek MA, Zhang J, Vanveldhuisen P, Troendle J, Beaver J, Hibbard JU. Contemporary labor patterns: the impact of maternal body mass index. Am J Obstet Gynecol 2011; 205 (03) 244.e1-244.e8
  • 7 Norman SM, Tuuli MG, Odibo AO, Caughey AB, Roehl KA, Cahill AG. The effects of obesity on the first stage of labor. Obstet Gynecol 2012; 120 (01) 130-135
  • 8 Nuthalapaty FS, Rouse DJ, Owen J. The association of maternal weight with cesarean risk, labor duration, and cervical dilation rate during labor induction. Obstet Gynecol 2004; 103 (03) 452-456
  • 9 Robinson BK, Mapp DC, Bloom SL. et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the Maternal-Fetal Medicine Units Network (MFMU). Increasing maternal body mass index and characteristics of the second stage of labor. Obstet Gynecol 2011; 118 (06) 1309-1313
  • 10 Vahratian A, Zhang J, Troendle JF, Savitz DA, Siega-Riz AM. Maternal prepregnancy overweight and obesity and the pattern of labor progression in term nulliparous women. Obstet Gynecol 2004; 104 (5 Pt 1): 943-951
  • 11 Leveno KJ, Nelson DB, McIntire DD. Second-stage labor: how long is too long?. Am J Obstet Gynecol 2016; 214 (04) 484-489
  • 12 Cheng YW, Hopkins LM, Caughey AB. How long is too long: does a prolonged second stage of labor in nulliparous women affect maternal and neonatal outcomes?. Am J Obstet Gynecol 2004; 191 (03) 933-938
  • 13 Le Ray C, Audibert F, Goffinet F, Fraser W. When to stop pushing: effects of duration of second-stage expulsion efforts on maternal and neonatal outcomes in nulliparous women with epidural analgesia. Am J Obstet Gynecol 2009; 201 (04) 361.e1-361.e7
  • 14 Allen VM, Baskett TF, O'Connell CM, McKeen D, Allen AC. Maternal and perinatal outcomes with increasing duration of the second stage of labor. Obstet Gynecol 2009; 113 (06) 1248-1258
  • 15 Rouse DJ, Weiner SJ, Bloom SL. et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Second-stage labor duration in nulliparous women: relationship to maternal and perinatal outcomes. Am J Obstet Gynecol 2009; 201 (04) 357.e1-357.e7
  • 16 Committee on Practice Bulletins—Obstetrics and the American Institute of Ultrasound in Medicine. Practice Bulletin No. 175: ultrasound in pregnancy. Obstet Gynecol 2016; 128 (06) e241-e256
  • 17 American College of Obstetricians and Gynecologists; Society for Maternal-Fetal Medicine. Gynecologists, Society for Maternal-Fetal M. Obstetric care consensus no. 1: safe prevention of the primary cesarean delivery. Obstet Gynecol 2014; 123 (03) 693-711
  • 18 Committee on Obstetric Practice. Committee Opinion No. 712: Intrapartum Management of Intraamniotic Infection. Obstet Gynecol 2017; 130 (02) e95-e101
  • 19 Schiessl B, Janni W, Jundt K, Rammel G, Peschers U, Kainer F. Obstetrical parameters influencing the duration of the second stage of labor. Eur J Obstet Gynecol Reprod Biol 2005; 118 (01) 17-20
  • 20 Piper JM, Bolling DR, Newton ER. The second stage of labor: factors influencing duration. Am J Obstet Gynecol 1991; 165 (4 Pt 1): 976-979
  • 21 Siggelkow W, Boehm D, Skala C, Grosslercher M, Schmidt M, Koelbl H. The influence of macrosomia on the duration of labor, the mode of delivery and intrapartum complications. Arch Gynecol Obstet 2008; 278 (06) 547-553
  • 22 Diegmann EK, Andrews CM, Niemczura CA. The length of the second stage of labor in uncomplicated, nulliparous African American and Puerto Rican women. J Midwifery Womens Health 2000; 45 (01) 67-71
  • 23 Bregand-White JM, Kominiarek MA, Hibbard JU. Hypertension and patterns of induced labor at term. Pregnancy Hypertens 2017; 10: 57-63
  • 24 Zhang J, Yu KF. What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA 1998; 280 (19) 1690-1691
  • 25 Hosmer DW, Lemeshow S, Sturdivant R. Applied Logistic Regression 3rd ed. New York: Wiley; 2013
  • 26 Gimovsky AC, Guarente J, Berghella V. Prolonged second stage in nulliparous with epidurals: a systematic review. J Matern Fetal Neonatal Med 2017; 30 (04) 461-465
  • 27 Bleich AT, Alexander JM, McIntire DD, Leveno KJ. An analysis of second-stage labor beyond 3 hours in nulliparous women. Am J Perinatol 2012; 29 (09) 717-722
  • 28 Conner SN, Tuuli MG, Longman RE, Odibo AO, Macones GA, Cahill AG. Impact of obesity on incision-to-delivery interval and neonatal outcomes at cesarean delivery. Am J Obstet Gynecol 2013; 209 (04) 386.e1-386.e6
  • 29 Zhang J, Bricker L, Wray S, Quenby S. Poor uterine contractility in obese women. BJOG 2007; 114 (03) 343-348
  • 30 Muir R, Ballan J, Clifford B. et al. Modelling maternal obesity: the effects of a chronic high-fat, high-cholesterol diet on uterine expression of contractile-associated proteins and ex vivo contractile activity during labour in the rat. Clin Sci (Lond) 2016; 130 (03) 183-192
  • 31 Conner SN, Verticchio JC, Tuuli MG, Odibo AO, Macones GA, Cahill AG. Maternal obesity and risk of postcesarean wound complications. Am J Perinatol 2014; 31 (04) 299-304
  • 32 Selo-Ojeme D, Sathiyathasan S, Fayyaz M. Caesarean delivery at full cervical dilatation versus caesarean delivery in the first stage of labour: comparison of maternal and perinatal morbidity. Arch Gynecol Obstet 2008; 278 (03) 245-249
  • 33 Tuuli MG, Liu L, Longman RE, Odibo AO, Macones GA, Cahill AG. Infectious morbidity is higher after second-stage compared with first-stage cesareans. Am J Obstet Gynecol 2014; 211 (04) 410.e1-410.e6
  • 34 Lurie S, Raz N, Boaz M, Sadan O, Golan A. Comparison of maternal outcomes from primary cesarean section during the second compared with first stage of labor by indication for the operation. Eur J Obstet Gynecol Reprod Biol 2014; 182: 43-47
  • 35 Brocato B, Lewis D, Mulekar M, Baker S. Obesity's impact on intrapartum electronic fetal monitoring. J Matern Fetal Neonatal Med 2019; 32 (01) 92-94
  • 36 Fyfe EM, Anderson NH, North RA. et al; Screening for Pregnancy Endpoints (SCOPE) Consortium. Risk of first-stage and second-stage cesarean delivery by maternal body mass index among nulliparous women in labor at term. Obstet Gynecol 2011; 117 (06) 1315-1322
  • 37 Weiss JL, Malone FD, Emig D. et al; FASTER Research Consortium. Obesity, obstetric complications and cesarean delivery rate--a population-based screening study. Am J Obstet Gynecol 2004; 190 (04) 1091-1097
  • 38 Rastogi S, Rojas M, Rastogi D, Haberman S. Neonatal morbidities among full-term infants born to obese mothers. J Matern Fetal Neonatal Med 2015; 28 (07) 829-835
  • 39 Scott-Pillai R, Spence D, Cardwell CR, Hunter A, Holmes VA. The impact of body mass index on maternal and neonatal outcomes: a retrospective study in a UK obstetric population, 2004-2011. BJOG 2013; 120 (08) 932-939