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J Pediatr Intensive Care 2019; 08(04): 255-258
DOI: 10.1055/s-0039-1695046
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Metformin Intoxication with Severe Renal Damage: An Adolescent Case Report

Ahmet Yontem 
1   Division of Pediatric Intensive Care Unit, Faculty of Medicine, Çukurova University, Adana, Turkey
,
Nagehan Aslan
1   Division of Pediatric Intensive Care Unit, Faculty of Medicine, Çukurova University, Adana, Turkey
,
Ozden Ozgur Horoz
1   Division of Pediatric Intensive Care Unit, Faculty of Medicine, Çukurova University, Adana, Turkey
,
Aysun Karabay Beyazit
2   Division of Pediatric Nephrology, Faculty of Medicine, Çukurova University, Adana, Turkey
,
Engin Melek
2   Division of Pediatric Nephrology, Faculty of Medicine, Çukurova University, Adana, Turkey
,
Dincer Yildizdas
1   Division of Pediatric Intensive Care Unit, Faculty of Medicine, Çukurova University, Adana, Turkey
› Author Affiliations Funding None.
Further Information

Publication History

03 June 2019

11 July 2019

Publication Date:
28 August 2019 (online)

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Abstract

Metformin is an oral antidiabetic medication which belongs to the class biguanide. Its most hazardous and life-threatening side effect is lactic acidosis which has been increasingly reported in recent years. Early diagnosis and aggressive treatment approaches have significantly reduced morbidity and mortality rates in metformin intoxication. In this case report, we emphasize the importance of early continuous renal replacement therapy in metformin-associated lactic acidosis in a 16-year-old patient who developed severe renal damage during the follow-up period of renal replacement therapy due to lactic acidosis after taking metformin in a suicide attempt.

Keywords

lactic acidosis - metformin - overdose - renal replacement therapy
 

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