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Synthesis 2020; 52(09): 1407-1416
DOI: 10.1055/s-0039-1691564
DOI: 10.1055/s-0039-1691564
paper
Palladium-Catalyzed ortho-Monoacylation of Arenes with Aldehydes via 1,2,4-Benzotriazine-Directed C–H Bond Activation
We thank the State Key Laboratory of Applied Organic Chemistry, Talent Introduction Project of Hubei Polytechnic University (No.19XJK03R), and Medical School (HBPU) for financial support.Further Information
Publication History
Received: 30 November 2019
Accepted after revision: 17 December 2019
Publication Date:
10 February 2020 (online)
Abstract
An efficient palladium-catalyzed C–H bond functionalization/ortho-monoacylation reaction of 3-aryl-1,2,4-benzotriazines with (hetero)aryl or alkyl aldehydes has been developed, which offers a facile and alternative strategy for direct modification and further diversification of 3-aryl-1,2,4-benzotriazines. Bioactive 1,2,4-benzotriazine has been employed as a novel directing group for the palladium-catalyzed regioselective monoacylation of sp2 C–H bond protocol with broad substrate scope and good functional group tolerance.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1691564.
- Supporting Information
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For representative reviews on C–H functionalization, see:
For representative reviews on directing-groups-assisted C–H functionalization, see:
For reviews on transition-metal-catalyzed directing-group-assisted acylation of the sp2 C–H bonds, see:
For selected examples, see:
For selected examples, see:
For selected examples, see:
For selected examples, see:
For selected examples, see:
For selected examples, see:
For selected examples, see:
For selected examples, see:
For selected examples, see: