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Synthesis 2020; 52(05): 735-743
DOI: 10.1055/s-0039-1691494
DOI: 10.1055/s-0039-1691494
paper
Studies towards the Total Synthesis of Kadcotrione B
Further Information
Publication History
Received: 08 September 2019
Accepted after revision: 05 November 2019
Publication Date:
21 November 2019 (online)
Abstract
A convergent and efficient approach towards the total synthesis of Kadcotrione B is described. For this purpose, the syntheses of two fragments, 6/6/5-fused tricyclic ring and C-9 side chain, were accomplished. The salient features of these syntheses are the utilization of aldol condensation, Evans aldol reaction, Horner–Wadsworth–Emmons olefination, Michael addition, Robinson annulation, and Wacker oxidation.
Key words
aldol condensation - diastereoselectivity - Hagiwara–Weiland–Miescher ketone - Horner–Wadsworth–Emmons reaction - Kadcotrione - Michael additionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1691494.
- Supporting Information
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