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Synlett 2020; 31(12): 1147-1157
DOI: 10.1055/s-0039-1690861
DOI: 10.1055/s-0039-1690861
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Recent Advances in Ruthenium-Catalyzed Carbene/Alkyne Metathesis (CAM) Transformations
This work has received financial support from the Ministerio de Economía y Competitividad (MINECO, projects CTQ2017-87939R and ORFEO-CINQA network RED2018-102387-T), the Xunta de Galicia (project ED431C 2018/04 and Centro singular de investigación de Galicia accreditation 2019–2022, ED431G 2019/03) and the European Union (European Regional Development Fund, ERDF). D.P. thanks the Ministerio de Educación, Cultura y Deporte for a predoctoral FPU fellowship (Grant Number FPU15/02132).Further Information
Publication History
Received: 17 February 2020
Accepted after revision: 02 March 2020
Publication Date:
31 March 2020 (online)
Abstract
Carbene intermediates have shown versatile applications in modern synthetic chemistry. Catalytic ruthenium carbene/alkyne metathesis (CAM) with readily available substrates renders an efficient procedure for the in situ generation of ruthenium vinyl carbene intermediates. Here, recent advances in synthetic applications of ruthenium-catalyzed carbene/alkyne metathesis (CAM) are highlighted.
1 Introduction
2 Ruthenium Vinyl Carbenes through Carbene/Alkyne Metathesis (CAM)
3 Nonpolar Transformations of Ruthenium Vinyl Carbenes
4 Polar Transformations of Ruthenium Vinyl Carbenes
4.1 Intramolecular Ruthenium-Catalyzed [1,5]- and [1,6]-Hydride Transfer/Cyclization
4.2 Heterocyclizations of Alkynals and Alkynones
4.3 Heterocyclizations of ortho-(Alkynyloxy)benzylamines
5 DFT Studies on the Stereoselectivity of the CAM Reaction
6 Conclusions
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