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J Pediatr Genet 2019; 08(01): 038-040
DOI: 10.1055/s-0039-1677749
Rapid Communication
Georg Thieme Verlag KG Stuttgart · New York

IL18 Gene Polymorphism Influences Age of Onset of DM1 in African Ancestry Brazilians

Alejandro Boëchat-Fernandes
1   Department of Genetics, Federal University of Paraná, Curitiba, Paraná, Brazil
,
Rosângela Roginski Réa
2   Endocrinology and Metabolism Service, University Hospital of the Federal University of Paraná, Curitiba, Paraná, Brazil
,
Nicole Balster Romanzini
2   Endocrinology and Metabolism Service, University Hospital of the Federal University of Paraná, Curitiba, Paraná, Brazil
,
Marilia Brito Gomes
3   Diabetes Unit, Department of Internal Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil
,
Lupe Furtado-Alle
1   Department of Genetics, Federal University of Paraná, Curitiba, Paraná, Brazil
,
Ricardo L. R. Souza
1   Department of Genetics, Federal University of Paraná, Curitiba, Paraná, Brazil
› Author Affiliations Funding Grants and scholarships were received from Coordination for Improvement of Higher Education (CAPES; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), National Research Council (CNPq), and Araucaria Foundation.
Further Information

Publication History

24 October 2018

24 December 2018

Publication Date:
30 January 2019 (online)

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Abstract

The aim of this study was to investigate the relationship of two single nucleotide polymorphisms (SNPs) in the interleukin-18 (IL18) gene (rs187238, g.-137G > C; rs1946518, g.-607C > A) and one SNP of the IL12B gene (rs3212227 g.*159A > C, 3′UTR) with the age of onset for type 1 diabetes mellitus (DM1). A total of 1,101 patients with DM1 enrolled in 13 centers from different regions of Brazil were genotyped with TaqMan assay and classified according to the ancestry. Our results show that an SNP in IL18 gene could be associated with DM1 age onset, taking into account that this studied variation affects gene expression.

Keywords

type 1 diabetes mellitus - IL18 - IL12B - polymorphism analysis

Ethical Publication Statement

We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.


Authors' Contributions

Alejandro Boëchat-Fernandes: experimental data and analysis.


Rosângela Roginski Réa: recruitment and diagnosis


Nicole Balster Romanzini: recruitment and diagnosis


Marilia Brito Gomes: study design.


Lupe Furtado-Alle: study design and analysis.


Ricardo L. R. Souza: study supervision.


 

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