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J Neurol Surg B Skull Base 2019; 80(03): 252-257
DOI: 10.1055/s-0038-1668516
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Tumor to Cerebellar Peduncle T2-Weighted Imaging Intensity Ratio Fails to Predict Pituitary Adenoma Consistency

Panagiotis Mastorakos
1   Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, United States
2   Department of Neurological Surgery, NIH/NINDS, Bethesda, Maryland, United States
,
Gautam U. Mehta
1   Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, United States
2   Department of Neurological Surgery, NIH/NINDS, Bethesda, Maryland, United States
3   Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States
,
Ajay Chatrath
1   Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, United States
,
Shayan Moosa
1   Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, United States
,
Maria-Beatriz Lopes
1   Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, United States
4   Department of Neuroathology, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, United States
,
Spencer C. Payne
5   Department of Otolaryngology, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, United States
,
John A. Jane Jr.
1   Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, United States
› Author Affiliations Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
This work has not been previously presented or published and is not under consideration for publication by any other journal.
Further Information

Publication History

16 March 2018

07 July 2018

Publication Date:
24 August 2018 (online)

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Abstract

Object The consistency of pituitary macroadenomas affects the complexity of surgical resection. On T2-weighted (T2W) imaging, the intensity ratio of the tumor to the cerebellar peduncle (tumor to cerebellar peduncle T2-weighted imaging intensity [TCTI] ratio) correlates with meningioma consistency. We aimed to determine the correlation of this radiographic finding with pituitary macroadenoma consistency and to determine whether it can be used for preoperative planning.

Methods We performed a retrospective evaluation of 196 patients with macroadenomas who underwent endoscopic transsphenoidal resection from January 2012 to June 2017. Macroadenoma consistency was determined by one senior neurosurgeon at the time of surgery. Axial and coronal T2W magnetic resonance imaging images were evaluated retrospectively, and adenoma size, Knosp grade, suprasellar extension and TCTI were calculated.

Results The mean TCTI ratio was 1.70 (95% confidence interval [CI]: 1.65–1.75). Intraoperatively, 140 (71.4%) adenomas were classified as soft and 48 (24.5%) as fibrous. Gross total resection was achieved in 66.7% of fibrous adenomas and in 86.4% of soft adenomas (p = 0.007). The mean ratio was 1.68 (95% CI: 1.62–1.74) for soft tumors and 1.76 (95%CI: 1.67–1.84) for fibrous tumors. There was no difference in the mean TCTI ratio between groups. Lactotroph and somatotroph adenomas had a lower mean TCTI ratio compared with other functioning and nonfunctioning adenomas with a mean TCTI of 1.52 compared with 1.77.

Conclusions In this retrospective cohort study, we found that the TCTI ratio does not correlate with tumor consistency. We also noted that the TCTI ratio is increased in prolactin and growth hormone-secreting adenomas.

Keywords

macroadenoma - pituitary adenoma - transsphenoidal - consistency - T2-weighted imaging intensity
 

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