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Thromb Haemost 1983; 50(02): 543-546
DOI: 10.1055/s-0038-1665251
Original Article
Schattauer GmbH Stuttgart

The Effect of N-6 and N-3 Polyunsaturated Fatty Acids on Hemostasis, Blood Lipids and Blood Pressure

J Z Mortensen
The Department of Clinical Chemistry, Section of Blood Coagulation, Aalborg Hospital, Aalborg, Denmark
,
E B Schmidt
The Department of Clinical Chemistry, Section of Blood Coagulation, Aalborg Hospital, Aalborg, Denmark
,
A H Nielsen
The Department of Clinical Chemistry, Section of Blood Coagulation, Aalborg Hospital, Aalborg, Denmark
,
J Dyerberg
The Department of Clinical Chemistry, Section of Blood Coagulation, Aalborg Hospital, Aalborg, Denmark
› Author Affiliations
Further Information

Publication History

Received 21 March 1983

Accepted 25 May 1983

Publication Date:
18 July 2018 (online)

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Summary

Diverging results from studies of marine oil supplementation to western diets initiated the undertaking of a double-blind crossover study, with administration to healthy volunteers for 4 weeks of either 10 g of fish oil or 10 g of vegetable oil. Each oil containing approx. 40% of n-3 and n-6 polyunsaturated fatty acids (PUFA) respectively. During the n-3 PUFA period, systolic blood pressure, plasma total lipids, triglycerides and VLDL concentrations fell significantly whereas plasma antithrombin-III (AT-III) rose. Cutaneous bleeding time increased significantly. In contrast only AT-III rose during the n-6 PUFA feeding, however, more marked than during the n-3 oil period. It is concluded that a n-3 PUFA oil supplement to the western diet exerts an effect that generally is considered as beneficial in terms of the risk of developing cardiovascular diseases. It is in this respect superior to that of n-6 PUFA, stressing the necessity of a more differentiated approach to advices on dietary PUFA enrichment than presently is exerted.

Keywords

Diet - PUFA’s - Platelet function - Hemostasis - Blood pressure
 

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