Effects of Oral Contraceptives and Obesity on Protein C Antigen

Summary

In 24 women using oral contraceptives, protein C antigen was higher than in 24 women of the same age and of the same degree of obesity who were not using OC. In the pooled data for all 48 women, there was an increase in protein C of about 1% (of standard) for each 1.0 mm increase in skinfold thickness. Protein C tends to be high rather than low in circumstances predisposing to thrombosis.

Keywords

Oral contraceptives - Protein C - Obesity

• References

• 1 Broekmans AW, Veltkamp JJ, Bertina R. Congenital protein C deficiency and venous thromboembolism. N Engl J Med 1983; 309: 340-344
• 2 Griffin JH, Evatt B, Zimmerman T, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981; 68: 1370-1373
• 3 Meade TW. Epidemiology of atheroma and thrombosis. In Haemostasis and Thrombosis. Bloom AL, Thomas DP. (Eds) Churchill Livingstone; 1981. pp 575-592
• 4 Meade TW, North WR S, Chakrabarti R, Haines AP, Stirling Y. Population-based distributions of haemostatic variables. Br Med Bull 1977; 33: 238-288
• 5 Mannucci PM, Vigano S. Déficiences of Protein C, an inhibitor of blood coagulation. Lancet 1982; 2: 463-467
• 6 Brozovic M, Stirling Y, Harricks C, North WR S, Meade TW. Factor VII in an industrial population. Br J Haematol 1974; 28: 381-391
• 7 Meade TW, Chakrabarti R, Haines AP, Howarth DJ, North WR S, Stirling Y. Haemostatic, lipid and blood pressure profiles of women on oral contraceptives containing 50 μg or 30 μg oestrogen. Lancet 1977; 2: 948-951
• 8 Viganò S, Mannucci PM, D’Angelo A, Gelfi C, Gensini GF, Rostagno C, Neri Serneri GG. Protein C antigen is not an acute phase reactant and is often high in ischemic heart disease and diabetes. Thromb Haemostas 1984; 52: 263-266
• 9 O’Connor NT J, Broekmans AW, Bertina RM. Protein C values in coronary artery disease. Br Med J 1984; 2: 1192