Download PDF
Thromb Haemost 1985; 53(02): 180-182
DOI: 10.1055/s-0038-1661268
Original Article
Schattauer GmbH Stuttgart

HTLV-I Antibody Status in Hemophilia Patients Treated with Factor Concentrates Prepared from U.S. Plasma Sources and in Hemophilia Patients with AIDS

T L Chorba
1   The Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
,
J M Jason
1   The Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
,
R B Ramsey
1   The Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
,
K Lechner
3   The Division of Hematology and Blood Coagulation, I. Department of Medicine, University of Vienna, Vienna, Austria
,
I Pabinger-Fasching
3   The Division of Hematology and Blood Coagulation, I. Department of Medicine, University of Vienna, Vienna, Austria
,
V S Kalyanaraman
2   The Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
,
J S McDougal
1   The Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
,
C D Cabradilla
2   The Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
,
L C Tregillus
1   The Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
,
D N Lawrence
1   The Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
,
B L Evatt
1   The Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia, USA
› Author Affiliations
Further Information

Publication History

Received 10 October 1984

Accepted 29 November 1984

Publication Date:
18 July 2018 (online)

  PDF Download  Permissions and Reprints

Summary

Serum samples from 85 Austrian hemophilia patients treated with lyophilized factor concentrates prepared from U.S. plasma sources, 24 hemophilia patients from Georgia on a home therapy program with factor concentrates, and 10 U.S. hemophilia patients with acquired immunodeficiency syndrome (AIDS) were analyzed by two different methods for the presence of antibodies to the major internal antigen of human T-cell leukemia virus I (HTLV-I) p24. All but one, a Georgia sample, were negative. The absence of antibody to HTLV-I p24 in the serum of European hemophilia patients, of U.S. hemophilia patients with no symptoms of AIDS, and of U.S. hemophilia patients with AIDS is interpreted as an indication of the lack of ready transmissibility of HTLV-I in lyophilized factor concentrates.

Keywords

HTLV - Hemophilia - Factor concentrates
 

  • References

  • 1 Saxinger WC, Gallo RC. Possible risk to recipients of blood from donors carrying serum markers of human T-cell leukaemia virus. Lancet 1982; 1: 1074
    PubMedGoogle Scholar
  • 2 Shimoyama M, Minata K, Tobinai K, Horikoshi N, Ikuba T, Deura K, Nagatani T, Ozaki Y, Inada N, Komoda H, Hinuma Y. Anti-ATLV (antibody to the adult T-cell leukemia cell associated antigen)-positive hematologic malignancies in the Kanto district. Jap J Clin Oncol 1982; 12: 109-116
    PubMedGoogle Scholar
  • 3 Miyoshi I, Fujishita M, Taguchi H, Ohtsuki Y, Akagi T, Morimoto Y, Nagasaki A. Caution against blood transfusion from donors seropositive to adult T-cell leukaemia-associated antigens. Lancet 1982; 1: 683-684
    PubMedGoogle Scholar
  • 4 Okochi K, Sato H, Hinuma Y. A retrospective study on transmission of adult T-cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang 1984; 46: 245-253
    CrossrefPubMedGoogle Scholar
  • 5 Blattner WA, Kalyanaraman VS, Robert-Guroff M, Lister TA, Galton DA G, Sarin PS, Crawford MH, Catovsky D, Greaves M, Gallo RC. The human type-C retrovirus, HTLV, in blacks from the Caribbean region, and relationship to adult T-cell leukemia/lymphoma. Int J Cancer 1982; 30: 257-264
    CrossrefPubMedGoogle Scholar
  • 6 Gallo RC, Kalyanaraman VS, Sarngadharan MG, Sliski A, Vonderheid EC, Maeda M, Nakao Y, Yamada K, Ito Y, Gutensohn N, Murphy S, Bunn PA, Catovsky D, Greaves MF, Blayney DW, Blattner W, Jarrett WF H, zur Hausen H, Seligmann M, Brouet JC, Haynes BF, Jegasothy BV, Jaffe E, Cossman J, Broder S, Fisher RI, Golde DW, Robert-Guroff M. Association of the human type C retrovirus with a subset of adult T-cell cancers. Cancer Res 1983; 43: 3892-3899
    PubMedGoogle Scholar
  • 7 Saxinger WC, Gallo RC. Possible risk to recipients of blood from donors carrying serum markers of human T-cell leukaemia virus (letter). Lancet 1982; 1: 1074
    PubMedGoogle Scholar
  • 8 Lee CA, Kemoff PB A, Bofill M, Rizza CR, Downing RG. HTLV and haemophilia. Lancet 1984; 1: 1028
    PubMedGoogle Scholar
  • 9 Blayney DW, Jaffe ES, Blattner WA, Cossman J, Robert-Guroff M, Longo DL, Bunn PA, Gallo RC. The human T-cell leukemia/ lymphoma virus associated with American adult T-cell leukemia/ lymphoma. Blood 1983; 2: 401-405
    PubMedGoogle Scholar
  • 10 Lechner K, Niessner H, Bettelheim P, Deutsch E, Fasching I, Fuhrmann M, Hinterberger W, Korninger C, Neumann E, Liszka K, Knapp W, Mayr WR, Stingl G, Zeitlhuber U. T-cell alternations in hemophiliacs treated with commercial clotting factor concentrates. Thromb Haemostas 1983; 50: 552-556
    PubMedGoogle Scholar
  • 11 Kalyanaraman VS, Cabradilla CD, Getchell JP, Narayanan R, Braff EH, Chermann JC, Barre-Sinoussi F, Montagnier L, Spira TJ, Kaplan J, Fishbein D, Jaffe HW, Curran JW, Francis DP. Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS. Science 1984; 225: 321-323
    CrossrefPubMedGoogle Scholar
  • 12 Kalyanaraman VS, Sarngadharan MG, Nakao Y, Ito Y, Aoki T, Gallo RC. Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan. Proc Natl Acad Sci USA 1982; 79: 1653-1657
    CrossrefPubMedGoogle Scholar
  • 13 Tsang VC W, Peralta JM, Simons AR. The enzyme-linked immunoelectro-transfer blot techniques (EITB) for studying the specificities of antigens and antibodies separated by gel electrophoresis. Methods Enzymol 1983; 92: 377-391
    PubMedGoogle Scholar
  • 14 Kalyanaraman VS, Sarngadharan MG, Poiesz BJ, Ruscetti FW, Gallo RC. Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses. J Virol 1981; 38: 906-915
    PubMedGoogle Scholar
  • 15 Popovic M, Sarin PS, Robert-Guroff M, Kalyanaraman VS, Mann D, Minowada J, Gallo RC. Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 1983; 219: 856-859
    CrossrefPubMedGoogle Scholar
  • 16 Clapham P, Nagy K, Cheingsong-Popov R, Exley M, Weiss RA. Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line. Science 1983; 222: 1125-1127
    CrossrefPubMedGoogle Scholar
  • 17 Miyoshi I, Taguchi H, Kubonishi I, Yoshimoto S, Ohtsuki Y, Shiraishi Y, Akagi T. Type C virus-producing cell lines derived from adult T- cell leukemia. In: Adult T-cell leukemia and related diseases. Hanaoka M, Takatsuki K, Shimoyama M. (eds) Plenum Press; New York: 1982. pp 219-228
    Google Scholar
  • 18 Gallo RC, Salahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, Palker TJ, Redfield R, Oleske J, Safai B, White G, Foster P, Markham PD. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 1984; 224: 500-502
    CrossrefPubMedGoogle Scholar
  • 19 Vilmer E, Rouzioux C, Vezinet Brun F, Fischer A, Chermann JC, Barre-Sinoussi F, Gazengel C, Dauguet C, Manigne P, Griscelli C, Montagnier L. Isolation of new lymphotropic retrovirus from two siblings with haemophilia B, one with AIDS. Lancet 1984; 1: 753-757
    PubMedGoogle Scholar
  • 20 Chermann JC, Barre-Sinoussi F, Montagnier L. Characterization and possible role in AIDS of a new human T-lymphotropic retrovirus. In Acquired immune deficiency syndrome. Gottlieb MS, Groopman JE. (eds) pp 31-46 Alan R.Liss Inc.; New York: 1984
    Google Scholar
  • 21 Feorino PM, Kalyanaraman VS, Haverkos HW, Cabradilla CD, Warfield DT, Jaffe HW, Harrison AK, Gottlieb MS, Goldfinger D, Chermann JC, Barre-Sinoussi F, Spira TJ, McDougal JS, Curran JW, Montagnier L, Murphy FA, Francis DP. Lymphadenopathy-associated virus infection of a blood donor-recipient pair with acquired immunodeficiency syndrome. Science 1984; 225: 69-72
    CrossrefPubMedGoogle Scholar
  • 22 Ramsey RB, Palmer EL, McDougal JS, Kalyanaraman VS, Jackson DW, Chorba TL, Holman RC, Evatt BL. Antibody to lymphadenopathy-associated virus in haemophiliacs with and without AIDS (letter). Lancet 1984; 2: 397-398
    PubMedGoogle Scholar
  • 23 Palmer EL, Ramsey RB, Feorino PF, Harrison AK, Cabradilla C, Francis DP, Poon M-C, Evatt BL. Isolation of HTLV from lymphocytes of two hemophiliacs with AIDS. Ann Intern Med 1984; 101: 293-297
    CrossrefPubMedGoogle Scholar
  • 24 Clauvel JP, Brouet JC, Maissonneuve P, Perol Y, Sultan Y. Etude des sous-populations lymphocytaires chez l’hémophile. Presse Med 1984; 13: 19-22
    PubMedGoogle Scholar
  • 25 Hanaoka M. Disease entity of adult T-cell leukemia: cytological aspects and geographic pathology. In Adult T-cell leukemia and related diseases. Hanaoka M, Takatsuki K, Shimoyama M. (eds) Plenum Press; New York: 1982. pp 1-2
    Google Scholar
  • 26 Blattner WA, Blayney DW, Robert-Guroff M, Sarngadharan MG, Kalyanaraman VS, Sarin PS, Jaffe ES, Gallo RC. Epidemiology of human T-cell leukemia/lymphoma virus. J Infect Dis 1983; 147: 406-416
    CrossrefPubMedGoogle Scholar
  • 27 Robert-Guroff M, Kalyanaraman VS, Blattner WA, Popovic M, Sarngadharan MG, Maeda M, Blayney D, Catovsky D, Bunn PA, Shibata A, Nakao Y, Ito Y, Aoki T, Gallo RC. Evidence for human T-cell lymphoma/leukemia virus infection of family members of human T-cell leukemia/lymphoma patients. J Exp Med 1983; 157: 248-258
    CrossrefPubMedGoogle Scholar