Download PDF
Thromb Haemost 1984; 52(03): 305-307
DOI: 10.1055/s-0038-1661201
Original Article
Schattauer GmbH Stuttgart

Urinary Excretion Rate of Antithrombin III Related Antigen in Cerebral Stroke

T Matsuo
1   The Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto, Japan
,
K Shinomiya
1   The Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto, Japan
,
S Okuno
1   The Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto, Japan
,
C Matsuo
2   The Department of Physiology, Kinki University School of Medicine, Sayama, Japan
,
O Matsuo
2   The Department of Physiology, Kinki University School of Medicine, Sayama, Japan
› Author Affiliations
Further Information

Publication History

Received 25 June 1984

Accepted 24 September 1984

Publication Date:
19 July 2018 (online)

  PDF Download  Permissions and Reprints

Summary

The urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 ± 1.61 × 10-4 ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor or further deteriorated including coma on admission, the excretion rate of AT III RA was 18.08 ± 2.50 × 10-4 ml/min. In group CH-II, whose consciousness state was clear on admission, the excretion rate of AT III RA was significantly lower than that in CH-I (6.20 ± 1.56 × 10-4 ml/min). The excretion rate in cerebral thrombosis (CT) was 1.96 ± 0.25 × 10-4 ml/min, which was significantly lower than that in CH. The excretion rate of AT III RA in both CH and CT was significantly higher than that in the healthy control group (0.29 ± 0.04 × 10-4 ml/min). Thus, AT III may change dynamically in cerebral stroke.

Key words

Antithrombin III - Excretion rate - Cerebral stroke - Sandwich immunoassay
 

  • References

  • 1 Rosenberg RD, Damus PS. The purification and mechanism of action of human antithrombin-heparin cofactor. J Biol Chem 1973; 248: 6490-6505
    PubMedGoogle Scholar
  • 2 Mortensen JZ, Jørgensen KA. Antithrombin. Dan Med Bull 1983; 30: 100-105
    PubMedGoogle Scholar
  • 3 Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thrombos Diathes Haemorrh 1965; 13: 516-541
    PubMedGoogle Scholar
  • 4 Matsuo O. Incidence of thrombosis in inherited antithrombin III deficiency. Thromb Res 1981; 24: 509-510
    CrossrefPubMedGoogle Scholar
  • 5 Tanaka M, Kato K. Determination of antithrombin III by sandwich enzymeimmunoassay. Thromb Res 1981; 22: 67-74
    CrossrefPubMedGoogle Scholar
  • 6 Miller-Anderson M, Borgh H, Andersson LO. Purification of antithrombin III by affinity chromatography. Thromb Res 1974; 5: 439-452
    CrossrefPubMedGoogle Scholar
  • 7 Collen D, De Cock F. Neoantigenic expression in enzyme-inhibitor complexes: a means to demonstrated activation of enzyme systems. Biochim Biophys Acta 1978; 525: 287-290
    CrossrefPubMedGoogle Scholar
  • 8 Kato K, Hamaguchi Y, Okawa S, Ishikawa E, Kobayashi K, Katunuma N. Use of rabbit antibody IgG-loaded silicone pieces for the sandwich enzyme-immunoassay of macromolecular antigens. J Biochem 1977; 81: 1557-1566
    PubMedGoogle Scholar
  • 9 Guyton A. Formation of urine by the kidney. In: Textbook of Medical Physiology. W B Saunders; Philadelphia/London: 1981. p 403
    Google Scholar
  • 10 Nakamura RM, Dito WR, Tucker III ES. Immunoassays. In: Clinical laboratory techniques for the 1980s. Alan R. Liss Inc; New York: 1980. p 1
    Google Scholar
  • 11 Biggs R, Denson WE, Akman N, Borret R, Hadden M. Antithrombin III, antifactor Xa and heparin. Br J Haematol 1970; 19: 283-305
    CrossrefPubMedGoogle Scholar
  • 12 Heimburger N, Haupt H, Schwick HG. Proteinase inhibitors of human plasma. In: Proceedings of the International Research Conference on Proteinase Inhibitors. Fritz H, Tschesche H. (eds) Walter de Gruyter; Berlin/New York: 1971. p 1
    Google Scholar
  • 13 Messmore HL. Natural inhibitors of coagulation system. Semin Thromb Hemostas 1982; 8: 267-275
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Collen D. Identification and some properties of a new fast-reacting plasmin inhibitor in human plasma. Eur J Biochem 1976; 69: 209-216
    CrossrefPubMedGoogle Scholar
  • 15 Moroi M, Aoki N. Isolation and characterization of α2-antiplasmin inhibitor from human plasma. J Biol Chem 1976; 251: 5956-5965
    PubMedGoogle Scholar
  • 16 Hougie C, Baugh RF. Current views on blood coagulation and haemostatic mechanism. In: Blood coagulation and haemostasis. Thomsom JM. (ed) 2. Edition Churchill Livingstone; Edinburgh/ London/New York: 1980. p 1
    Google Scholar
  • 17 Collen D, De Cock F, Verstraete M. Quantitation of thrombinantithrombin III complex in human blood. Eur J Clin Invest 1977; 7: 407-411
    CrossrefPubMedGoogle Scholar
  • 18 Mettinger KL, Nyman D, Kjellin KG, Sidén Å, Söderström CE. Factor VIII related antigen, antithrombin III, spontaneous platelet aggregation and plasminogen activator in ischemic cerebrovascular disease. J Neurol Sci 1979; 41: 31-38
    CrossrefPubMedGoogle Scholar
  • 19 Wahlberg JB, Blombäck M, Overmark I. Blood coagulation studies in 45 patients with ischemic cerebrovascular disease and 44 patients with venous thromboembolic disease. Acta Med Scand 1980; 207: 385-390
    PubMedGoogle Scholar
  • 20 Marra R, Pagano L, De Stefano V, Bizzi B. Antithrombin III and factor Xa inhibitor in atherosclerosis. Haemostasis 1983; 13: 209-213
    PubMedGoogle Scholar
  • 21 Vermylen J. Physiology of haemostasis. In: Platelet: A multidisciplinary approach. De Gaetano G, Garattini S. (eds) Raven Press; New York: 1978. p 3
    Google Scholar