Thromb Haemost 1984; 52(02): 216
DOI: 10.1055/s-0038-1661178
Letter to the Editor
Schattauer GmbH Stuttgart

L-Asparaginase Lowers Protein C Antigen

Tiziano Barbui
Divisione di Ematologia, Ospedali Riuniti, largo Barozzi 1, Bergamo, Italy
,
Guido Finazzi
Divisione di Ematologia, Ospedali Riuniti, largo Barozzi 1, Bergamo, Italy
,
Silvana Viganò
1   The Haemophilia and Thrombosis Centre Angelo Bianchi Bonomi, University of Milano, via Pace 9, Milano, Italy
,
Pier Mannuccio Mannucci
1   The Haemophilia and Thrombosis Centre Angelo Bianchi Bonomi, University of Milano, via Pace 9, Milano, Italy
› Author Affiliations
Further Information

Publication History

Received 04 June 1984

Accepted 20 July 1984

Publication Date:
19 July 2018 (online)

 
  • References

  • 1 Priest JR, Ramsay NK C, Steinherz PG. et al. A syndrome of thrombosis and hemorrhage complicating L-asparaginase therapy for childhood acute lymphoblastic leukemia. J Pediatr 1982; 100: 984-989
  • 2 Pitney WR, Phadke KP, Dean S. Antithrombin III deficiency during asparaginase therapy. Lancet 1980; 1: 493-494
  • 3 Barbui T, Rodeghiero F, Meli S, Dini E. Fatal pulmonary embolism and antithrombin III deficiency in adult lymphoblastic leukemia during L-asparaginase therapy. Acta Haematol 1983; 69: 188-191
  • 4 Bauer KA, Teitel JM, Rosenberg RD. L-asparaginase induced antithrombin III deficiency: evidence against the production of a hypercoagulable state. Thromb Res 1983; 29: 437-442
  • 5 Mannucci PM, Viganò S. Deficiencies of Protein C, an inhibitor of blood coagulation. Lancet 1982; 2: 463-467