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Thromb Haemost 1984; 52(02): 154-156
DOI: 10.1055/s-0038-1661161
Original Article
Schattauer GmbH Stuttgart

Masking of Fibrinolytic Response to Stimulation by an Inhibitor of Tissue-Type Plasminogen Activator in Plasma

E J P Brommer
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
J H Verheijen
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
G T G Chang
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
D C Rijken
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 04 December 1983

Accepted 03 July 1984

Publication Date:
19 July 2018 (online)

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Summary

Patients with hyperlipoproteinaemia or spontaneous thromboembolism, known to be poor responders to DDAVP or to venous occlusion with regard to the rise in fibrinolytic activity of the blood, appeared to show a normal increase in t-PA-antigen after the same procedure. In their plasma a higher than normal level of free, fast-acting t-PA-inhibitor was found as measured by titration with purified t-PA. This free t-PA-inhibitor level only decreased after the test, in contrast to its complete disappearance in normal responders. The same happened in a healthy volunteer who failed to exhibit a rise in fibrinolytic activity after exhaustive exercise.

We suppose that the lack of response of the fibrinolytic activity in these cases is due to a high inhibitor level and not to impaired release of t-PA into the blood.

In contrast, patients with terminal renal insufficiency showed only a slight increase in t-PA-antigen after DDAVP. The level of free fast-acting inhibitor was normal in most cases and did not change appreciably during DDAVP-infusion. In these patients, a true impairment of the release of t-PA appears to exist.

Keywords

t-PA-inhibitor - Standard - DDAVP - Exercise - Venous occlusion
 

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