Download PDF
Thromb Haemost 1984; 51(02): 240-242
DOI: 10.1055/s-0038-1661067
Original Article
Schattauer GmbH Stuttgart

Effect of Venous Stasis on Vessel Wall Fibrinolysis

Björn Stenberg
The Department of Surgery I and Arterial Biology Group, Sahlgrenska Sjukhuset, University of Göteborg, Sweden
,
Anders Bylock
The Department of Surgery I and Arterial Biology Group, Sahlgrenska Sjukhuset, University of Göteborg, Sweden
,
Bo Risberg
The Department of Surgery I and Arterial Biology Group, Sahlgrenska Sjukhuset, University of Göteborg, Sweden
› Author Affiliations
Further Information

Publication History

Received 22 November 1983

Accepted 09 February 1984

Publication Date:
19 July 2018 (online)

  PDF Download  Permissions and Reprints

Summary

The effects of prolonged venous stasis on release of plasminogen activators (PA) from the caval vein of rats were studied.

PA activity was continuously reduced in the intimal layer and after 8 hr of stasis the reduction was statistically significant. After 2 and 3 days no intimal PA activity was found. The PA activity in the adventitial vasa vasorum was unchanged during the experimental period.

Keywords

Stasis - Endothelium - Fibrinolysis
 

  • References

  • 1 Romanus M, Risberg B. Fibrinolysis in the ischemic hamster cheek pouch. Thromb Res 1978; 12: 421-429
    CrossrefPubMedGoogle Scholar
  • 2 Risberg B. Fibrinolysis in grafted arteries and veins. Thromb Haemostas 1978; 40: 512-517
    PubMedGoogle Scholar
  • 3 Mysliwiec M, Villa S, Kronblatt L, de Gaetano G, Donati MB. Decreased plasminogen activator but normal prostacyclin activity in rat veins during development of experimental thrombosis. Thromb Res 1980; 18: 159-165
    CrossrefPubMedGoogle Scholar
  • 4 Todd AS. Histochemical localization of fibrinolysin activator. J Path Bact 1959; 78: 281-283
    CrossrefPubMedGoogle Scholar
  • 5 Risberg B. Fibrinolysis in the lung. Acta Chir Scand 1975; (Suppl. 458) (Suppl) 1-36
    PubMedGoogle Scholar
  • 6 Loskutoff DJ. Effect of thrombin on the fibrinolytic activity of cultured bovine endothelial cells. J Clin Invest 1979; 64: 329-332
    CrossrefPubMedGoogle Scholar
  • 7 Kluft C. Blood fibrinolysis. Thesis; Leiden: 1978
    Google Scholar
  • 8 Rijken DC, Wijngaards G, Welbergen J. Relationship between tissue plasminogen activator and the activators in blood and vascular wall. Thromb Res 1980; 18: 815-830
    CrossrefPubMedGoogle Scholar
  • 9 Clarke RL, Orandi A, Cliffton EE. Induction of fibrinolysis by venous obstruction. Angiology 1960; 2: 367-370
    PubMedGoogle Scholar
  • 10 Robertsson BR, Pandolfi M, Nilsson IM. »Fibrinolytic capacity« in healthy volunteers as estimated from the effect of venous occlusion of arms. Acta Chir Scand 1972; 138: 429-436
    PubMedGoogle Scholar
  • 11 Wu A, Mansfield AO. The fibrinolytic activity in the vein following venous stasis. Br J Surg 1979; 66: 637-639
    CrossrefPubMedGoogle Scholar
  • 12 Juhan-Vague I, Aillaud MF, Juhan C, Kadji H, Choux R, Barrat E. Fibrinolytic activity in experimental vascular grafts. Haemostasis 1983; 13: 119-135
    PubMedGoogle Scholar
  • 13 Szczepański M, Nilsson IM. The fibrinolytic activity in tissues during the peripheral venous occlusion in rat. Thrombos Diathes Haemorrh 1970; 24: 522-529
    PubMedGoogle Scholar
  • 14 Kumada T, Ischihara M, Ogawa H, Abiko Y. Experimental model of venous thrombosis in rats and effect of some agents. Thromb Res 1980; 18: 189-203
    CrossrefPubMedGoogle Scholar
  • 15 Constantini R, Spüttl F, Holzknecht F, Braunsteiner H. On the role of the stable plasminogen activator of the venous wall in occlusion induced fibrinolytic state. Thrombos Diathes Haemorrh 1969; 22: 544-551
    PubMedGoogle Scholar
  • 16 Larsson J, Risberg B. Fibrinolytic activity in human legs in tomiquet ischemia. Thromb Res 1977; 11: 817-825
    CrossrefPubMedGoogle Scholar
  • 17 Constantini R, Hilbe G, Holzknecht F, Aschauer R. The effect of experimental arterial occlusion on the plasminogen tissue activator in rabbits. Angiology 1974; 24: 603-605
    PubMedGoogle Scholar