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Thromb Haemost 1983; 49(03): 168-172
DOI: 10.1055/s-0038-1657354
Original Article
Schattauer GmbH Stuttgart

Platelet Abnormalities in Muscular Dystrophy

R Yarom
The Departments of Pathology and Hematology, Hadassah University Hospital and Alyn Hospital for Crippled Children, Jerusalem, Israel
,
S Meyer
The Departments of Pathology and Hematology, Hadassah University Hospital and Alyn Hospital for Crippled Children, Jerusalem, Israel
,
R More
The Departments of Pathology and Hematology, Hadassah University Hospital and Alyn Hospital for Crippled Children, Jerusalem, Israel
,
M Liebergall
The Departments of Pathology and Hematology, Hadassah University Hospital and Alyn Hospital for Crippled Children, Jerusalem, Israel
,
A Eldor
The Departments of Pathology and Hematology, Hadassah University Hospital and Alyn Hospital for Crippled Children, Jerusalem, Israel
› Author Affiliations
Further Information

Publication History

Received 12 February 1982

Accepted 17 March 1983

Publication Date:
18 July 2018 (online)

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Summary

Platelets which have complex membranes and calcium shifts similar to those in muscles were investigated in 14 patients with muscular dystrophy and 20 suitable controls. In 4 Duchenne and one limb-girdle dystrophy aggregations were done and found to be depressed with adrenaline and ADP. Electron microscopic and chemical examinations revealed an increased number of dense bodies, changed permeability and/or binding of cations and elevated intracellular calcium in all the 9 cases of Duchenne dystrophy while the 2 limb-girdle and 3 myotonic dystrophies varied.

A two phase polymer separation system applied to fixed platelets of all patients and controls showed no abnormality of surface negative charge.

Keywords

Platelet calcium - Adrenaline aggregation - Surface-charge
 

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