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Thromb Haemost 1997; 77(03): 504-509
DOI: 10.1055/s-0038-1655997
Coagulation
Schattauer GmbH Stuttgart

Dietary Vitamin and Stability of Oral Anticoagulation: Proposal of a Diet with Constant Vitamin K1 Content

Sarah L Booth
1   The Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, USA
,
Jacqueline M Charnley
2   The Dept. of Local Health, State of Vermont, USA
,
James A Sadowski
1   The Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, USA
,
Edward Saltzman
1   The Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, USA
,
Edwin G Bovill
3   The Dept. of Local Health, University of Vermont, Burlington, USA
,
Mary Cushman
3   The Dept. of Local Health, University of Vermont, Burlington, USA
› Author Affiliations
Further Information

Publication History

Received 13 June 1996

Accepted after resubmission 12 November 1996

Publication Date:
11 July 2018 (online)

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Summary

Case reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K1 content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K1, equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K1-coumarin interaction. The dietary guidelines reported here may be used in such studies.

 

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