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Thromb Haemost 1997; 77(03): 434-435
DOI: 10.1055/s-0038-1655983
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Schattauer GmbH Stuttgart

Detection of Polymorphisms in the Human Urokinase-type Plasminogen Activator Gene

B Conne
The Département de Pathologie, Centre medical universitaire, Geneva, Switzerland
,
M Berczy
The Département de Pathologie, Centre medical universitaire, Geneva, Switzerland
,
D Belin
The Département de Pathologie, Centre medical universitaire, Geneva, Switzerland
› Author Affiliations
Further Information

Publication History

Received 11 September 1996

Accepted after revision 18 November 1996

Publication Date:
11 July 2018 (online)

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Summary

Expressed polymorphisms in the genes encoding components of the fibrinolytic cascade could have implications for the predisposition to thrombolytic disorders and/or for tumor metastasis. The occurrence of published two amino acid sequences at position 194 of the human urokinase-type plasminogen activator prompted us to search by SSCP for frequent polymorphisms in several exons of the gene. Surprisingly, only one sequence was detected in codon 194 (>200 alleles). Two polymorphisms were observed in this study: the most frequent one, a C to T change near the beginning of exon 8, is probably silent; a less frequent polymorphism results in the replacement of a Leu residue by a Pro, in the kringle domain.

 

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