Thromb Haemost 1963; 09(01): 120-125
DOI: 10.1055/s-0038-1654966
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

An in vivo Trial of an Anti-Adhesive Drug

J. R O‘Brien M.A., D.M., M.R.C.S., L.R.C.P.
1   Portsmouth and Isle of Wight Area Pathological Service, Milton Road, Portsmouth, England
› Author Affiliations
Further Information

Publication History

Publication Date:
21 June 2018 (online)

Summary

Ro-30837 given by mouth to seven people produced a variable but definite prolongation of the bleeding time and greater blood loss. This effect was probably due to a decrease in platelet adhesiveness.

 
  • References

  • 1 Borchgrevink C. F. A method for measuring platelet adhesiveness in vivo. Acta, med. scand. 168: 157-164 1960;
  • 2 Bounameaux Y. Antihistaminiques de synthèse et retraction du caillot. Arch. int. Pharmacodyn 116: 252-254 1958;
  • 3 Gough K. R. Capillary resistance to suction in hypertension. Brit. med. J. 01: 21-24 1962;
  • 4 Kjaerheim A, Hovig T. The ultrastructure of haemostatic blood platelet plugs in rabbit mesenterium. Thrombos. Diathes. haemorrh. 07: 1-15 1962;
  • 5 McDonald L, Edgill M. Action of heparin in ischaemic heart-disease. Lancet 01: 844-847 1961;
  • 6 O’Brien J. R. The adhesiveness of native platelets and its prevention. J. clin. Path. 14: 140-149 1961;
  • 7 O’Brien J. R. Platelet aggregation: Part I Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesiveness. Part II Some results from a new method of study. J. clin. Path. 15: 446-455 1962;
  • 8 Poole J. C. F, French J. E. Thrombosis. J. Atheroscler. Res. 01: 251-282 1961;
  • 9 Shimamoto J. Damages to “silicone-like property” of vascular endothelial cells and prevention by monoamino oxidase inhibitor, Nialamide. Asian Med. J. 03: 479-492 1960;