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Thromb Haemost 1995; 73(02): 239-242
DOI: 10.1055/s-0038-1653757
Original Article
Coagulation
Schattauer GmbH Stuttgart

Dietary Changes in Fasting Levels of Factor VII Coagulant Activity (FVII: C) Are Accompanied by Changes in Factor VII Protein and other Vitamin K-dependent Proteins

E M Bladbjerg
1   The Institute for Thrombosis Research, South Jutland University Centre, Esbjerg, and Department of Clinical Biochemistry, Ribe County Hospital in Esbjerg, Denmark
,
T Tholstrup
2   The Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
,
P Marckmann
2   The Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
,
B Sandström
2   The Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
,
J Jespersen
1   The Institute for Thrombosis Research, South Jutland University Centre, Esbjerg, and Department of Clinical Biochemistry, Ribe County Hospital in Esbjerg, Denmark
› Author Affiliations
Further Information

Publication History

Received 14 June 1994

Accepted after revision 11 October 1994

Publication Date:
09 July 2018 (online)

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Summary

The mechanisms behind dietary effects on fasting coagulant activity of factor VII (FVII: C) are not clarified. In the present study of 15 young volunteers, two experimental diets differing in composition of saturated fatty acids (C18:0 [diet S] or C12:0 + C14:0 [diet ML]) were served for 3 weeks each. Fasting blood samples were collected before and after the dietary regimen and analysed for triglycerides, FVII:C, and protein concentrations of FVII, FII, FX, protein C, CRP, albumin, fibrinogen, and F1+2. FVII:C was significantly reduced on diet S compared with diet ML. This was accompanied by a decrease in FVII protein, F1+2 and the vitamin K-dependent proteins FII, FX, and protein C. In contrast, no changes were observed in triglycerides, FVII:C/FVII: Ag, albumin and CRP. Fibrinogen was increased on diet S compared with diet ML. Our findings suggest that the change in fasting FVII:C was part of a general change in concentrations of vitamin K-dependent proteins.

 

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