Download PDF
Thromb Haemost 1969; 21(02): 196-202
DOI: 10.1055/s-0038-1653528
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

Erythrocyte Sedimentation and Soluble Fibrin Monomer Complexes

B Lipiński   1)
1   Department of Physiological Chemistry, Medical School, Białystok, Poland
,
K Worowski
1   Department of Physiological Chemistry, Medical School, Białystok, Poland
,
M Myśliwiec
1   Department of Physiological Chemistry, Medical School, Białystok, Poland
,
R Farbiszewski
1   Department of Physiological Chemistry, Medical School, Białystok, Poland
› Author Affiliations
Further Information

Publication History

Publication Date:
28 August 2018 (online)

    Permissions and Reprints

Summary

It is shown in the present work that highly significant correlation (r = 0.836) exists between the level of SFMC and the erythrocyte sedimentation rate in blood of 56 patients. No correlation of ESR with fibrinogen content was observed in 1 patient during the post-operative period, as well as in the group of experimentally infected rabbits. Administration of fibrinolysis inhibitors into rabbits (EACA, IP-315, HgCl2) caused in all cases a significant increase in ESR and in plasma SFMC with unrelated elevation of the fibrinogen level. Protamine sulphate added to whole blood with high ESR to final concentration 1 mg/ml of blood completely abolished the sedimentation of erythrocytes. A hypothesis is formulated according to which red cells interacting with SFMC increase their sedimentation rate.

1) Present adress: Department of Biochemistry, Postgraduate Medical School, Marymoncka 99, Warszawa, Poland.


 

  • References

  • 1 Biernacki E. Samoistna sedymentacja krwi, jako naukowa i praktyczno-kliniczna metoda badania. Gazeta Lekarska 17: 962 1897;
    PubMedGoogle Scholar
  • 2 Ditzel J, Bang H. O, Thorsen N. Myocardial infarction and whole-blood viscosity. Acta med. scand 183: 577 1968;
    PubMedGoogle Scholar
  • 3 Elliott F. A, Buckell M. Fibrinogen changes in ralation to cerebrovascular accidents. Neurology 11: 129 1961;
    PubMedGoogle Scholar
  • 4 Kopec M, Wegrzynowicz Z, Budzynski A. Z, Latallo Z. S, Lipinski B, Kowalski E. Interaction of fibrinogen degradation products (FDP) with platelets. Exp. Biol. Med 03: 73 1968;
    PubMedGoogle Scholar
  • 5 Kowalski E, Kopec M, Niewiarowski S. An evaluation of the euglobulin method for determination of fibrinolysis. J. clin. Path 12: 215 1959;
    CrossrefPubMedGoogle Scholar
  • 6 Lipinski B. Soluble fibrin monomer complexes. Post. Bioch 14: 373 1968;
    PubMedGoogle Scholar
  • 7 Lipinski B, Hawiger J, Jeljaszewicz J. Staphylococcal clumping with soluble fibrin monomer complexes. J. exp. Med 126: 979 1967;
    CrossrefPubMedGoogle Scholar
  • 8 Lipinski B, Worowshi K. Detection of soluble fibrin monomer complexes in blood by emans of protamine sulphate test. Thrombos. Diathes. haemorrh. (Stuttg.) 20: 44 1968;
    PubMedGoogle Scholar
  • 9 Lipinski B, Worowski K, Jeljaszewicz J, Niewiarowski S, Rejniak L. Participation of soluble fibrin monomer complexes and platelet factor 4 in the generalized Shwartzman reaction. Thrombos. Diathes. haemorrh. (Stuttg.) 20: 285 1968;
    PubMedGoogle Scholar
  • 10 Luchini B. W, Copley A. L. Fibrinogen-fibrin complexes in relation to the sedimentation properties of blood. Proc. XII Congr. Int. Soc. Hematol. New York: 1968: 192.
    Google Scholar
  • 11 Quick A. J. The physiology and pathology of haemostasis. Kimpton; London: 1951
    Google Scholar
  • 12 Persson I. Variations in the plasma fibrinogen during the course of multiple sclerosis. Arch. Neurol. Psych 74: 17 1955;
    CrossrefPubMedGoogle Scholar
  • 13 Rapaport S. I, Ames S. B. Antiheparin activity of erythrocyte hemolysate. Proc. Soc. exp. Biol. (N. Y.) 95: 158 1957;
    CrossrefPubMedGoogle Scholar
  • 14 von Rieche K. Die Schnellbestimmung des Plasmafibrinogens mit Protaminsulfat. Z. med. Labortechnik 08: 217 1967;
    PubMedGoogle Scholar
  • 15 Ruhenstroth-Bauer G. Mechanism and significance of erythrocyte sedimentation rate. Brit, med. J No. 5242, 1804 1961;
    PubMedGoogle Scholar
  • 16 Stachurska J, Szpilman H, Lipinski B. A new method for determination of soluble fibrin monomer complexes in whole blood samples. Experientia (Basel) (Submitted for publication).
    PubMedGoogle Scholar
  • 17 Westergren A. Sedimentation of erythrocyte test. Acta med. scand., Suppl 07: 102 1924;
    PubMedGoogle Scholar
  • 18 Wintrobe M. M, Landsberg J. W. A standard technique for blood sedimentation test. Amer. J. Sci 189: 102 1935;
    PubMedGoogle Scholar
  • 19 Worowski K, Lipinski B, Cybulska J, Jeljaszewicz J. Disturbances in blood clotting and fibrinolysis in experimental staphylococcal infection. J. inf. Dis. (Submitted for publication.)
    PubMedGoogle Scholar