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Thromb Haemost 1975; 34(03): 770-779
DOI: 10.1055/s-0038-1651470
Original Article
Schattauer GmbH

Evans Blue: A Specific Inhibitor of Factor VIII-Induced Platelet Agglutination

E. P Kirby
1   Department of Biochemistry and the Specialized Center for Thrombosis Research, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140
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Further Information

Publication History

Received 14 April 1975

Accepted 16 May 1975

Publication Date:
02 July 2018 (online)

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Summary

Low concentrations of Evans Blue ( < 1 μM) inhibit the agglutination of formalin-treated platelets by bovine Factor VIII or by human Factor VIII in the presence of the antibiotic ristocetin. Evans Blue is a specific inhibitor of this reaction and acts by inhibiting the binding of Factor VIII to the platelet surface.

 

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