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Thromb Haemost 1975; 34(03): 740-747
DOI: 10.1055/s-0038-1651467
Original Article
Schattauer GmbH

Calculation of Predictive Odds for Possible Carriers of Haemophilia

C. R. M Prentice
1   Departments of Medicine and Statistics, Glasgow University, Scotland
,
C. D Forbes
1   Departments of Medicine and Statistics, Glasgow University, Scotland
,
Sandra Morrice
1   Departments of Medicine and Statistics, Glasgow University, Scotland
,
A. D McLaren
1   Departments of Medicine and Statistics, Glasgow University, Scotland
› Author Affiliations
Further Information

Publication History

Received 24 March 1975

Accepted 17 July 1975

Publication Date:
02 July 2018 (online)

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Summary

Betting odds for possible carriers of haemophilia have been calculated using data derived from normal and known carrier populations. For each possible carrier the concentration of factor VIII-related antigen and factor VIII biological activity was measured and used to determine the probability of the individual being a carrier. The calculations indicated that, of the 32 possible carriers, 11 were likely to be normal (odds of more than 5:1) while 11 were likely to be haemophilia carriers (again odds of more than 5:1).

 

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