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Thromb Haemost 1969; 22(02): 273-280
DOI: 10.1055/s-0038-1651353
Originalarbeiten-Original Articles-Travaux Originaux
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Coagulation Studies of Cord Blood, with Special Reference to “Fetal Fibrinogen”[*]

A von Felten
1   Department of Internal Medicine, Kantonsspital, University of Zürich
,
P. W Straub
1   Department of Internal Medicine, Kantonsspital, University of Zürich
› Author Affiliations
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Publication History

Publication Date:
10 June 2018 (online)

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Summary

The last phase of the clotting mechanisms was investigated in cord blood of 118 mature newborns.

The most prominent finding was a prolonged thrombin time, not due to heparin. It was accompanied in most cases by a low fibrinogen and in some by a gelatinous appearance of the clot and a paracoagulation of the serum. This association was found to be usually due to in vitro fibrinogenolysis with consequent appearance of fibrinogen split products.

In 9 cases the prolonged thrombin time was not obviously due to fibrinogen degradation products. The possibilities of the presence of high molecular weight fibrinogen degradation products or of a special characteristic of cord blood fibrinogen leading to a delayed fibrinogen-fibrin conversion are considered.

* Study performed with the aid of the Hartmann Mueller Foundation for medical research.


 

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