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Thromb Haemost 1980; 43(02): 141-146
DOI: 10.1055/s-0038-1650036
Original Article
Schattauer GmbH Stuttgart

A New Hypothesis: Possible Mechanisms in the Involvement of the Increased Plasminogen Activator Activity in Branching Regions of the Aorta in the Initiation of Atherosclerosis

A Smokovitis
The Gaubius Institute, Health Research Organization TNO, Leiden, The Netherlands; Department of Physiology, School of Medicine, University of Vienna, Vienna, Austria
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Further Information

Publication History

Received 23 November 1979

Accepted 23 February 1980

Publication Date:
26 July 2018 (online)

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Summary

Branching regions of the aorta are predilection regions for atherosclerosis. The intima in the branching regions of the normal aorta shows a constantly increased plasminogen activator activity from early life. At these areas, the endothelium is also damaged, it shows increased permeability, etc. The constantly increased plasminogen activator activity (local plasmin production) might play a protective role or on the contrary might participate in the initiation of atherosclerosis at the branching regions through a number of proved or suggested mechanisms.

No matter what the actual role of the locally increased plasminogen activator activity in the initiation of atherosclerosis is, the role of the fibrinolytic system in the progression of the atherosclerotic lesion seems to be clear. There is an accumulation of evidence that the impaired fibrinolytic activity in atherosclerotics participates in the progression and the complications of the disease.

Keywords

Atherosclerosis - Branching regions - Plasminogen activator - Plasmin - Initiation of atherosclerosis - Progression of atherosclerosis - Fibrinolysis
 

  • References

  • 1 Smokovitis A. Regions of constantly increased plasminogen activator activity along the intima of the normal aorta. Haemostasis 1978; 7: 303-319
    PubMedGoogle Scholar
  • 2 Glas-Greenwalt P. Latent and manifest endothelial fibrinolysis. Third Int Congr on Thrombosis and Haemostasis, Washington D C, 1972 (Abstr 290); personal communication
    PubMedGoogle Scholar
  • 3 Noordhoek HegtV. Distribution and variation of fibrinolytic activity in the walls of human arteries and veins. Haemostasis 1976; 5: 355-372
    PubMedGoogle Scholar
  • 4 Astrup T, Albrechtsen OK, Claessen M, Rasmussen J. Thrombo-plastic and fibrinolytic activity of the human aorta. Circulation Res 1959; 7: 969-976
    CrossrefPubMedGoogle Scholar
  • 5 Donner L, Klener P, Roth Z. The plasminogen activator of the arterial wall. Thromb Haemost 1977; 37: 436-443
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Onoyama K, Tanaka K. Fibrinolytic activity of the arterial wall. Thromb Diath haemorrh 1969; 21: 1-11
    PubMedGoogle Scholar
  • 7 Pelczar ME, Glas-Greenwalt P, Astrup T. Primary pulmonary aspergillosis with high fibrinolytic activity in the aortic intima. Chest 1972; 61: 394-396
    CrossrefPubMedGoogle Scholar
  • 8 Smokovitis A, Binder BR. The effect of alloxan-induced diabetes on tissue plasminogen activator activity of the rat. Thromb Haemost 1979; 42: 333 (Abstr); paper in preparation
    PubMedGoogle Scholar
  • 9 Smokovitis A, Auerswald W, Binder BR. Induced changes in the endothelial plasminogen activator activity of the rat aorta. Fifth Meeting of the International Society of Haematology, Hamburg 1979; Vol 2 p 48 (Abstr)
    PubMedGoogle Scholar
  • 10 Smokovitis A, Binder BR. Wirkung des anabolen Steroids Stanozolol auf die fibrinolytische Aktivität bei der Ratte. I Kongreß für Thrombose und Blutgerinnung. Schattauer Verlag (in press); Blut: 1980. 40 174 (Abstr). Experientia 1980 (in press)
    Google Scholar
  • 11 Smokovitis A, Auerswald W, Binder BR. Endothelzellen-Plasminogen-Aktivator-Aktivität (PAA) bei genetisch hypercholesterinämischen Ratten (RICO); Wirkung von Streptozotocin auf die Endothelzell-PAA. I Kongreß für Thrombose und Blutgerinnung. Schattauer Verlag (in press); Blut: 1980. 40 173 (Abstr)
    Google Scholar
  • 12 Smokovitis A, Auerswald W, Binder BR. Wechselwirkung zwischen Streptozotocin und Dexamethason auf die Plasminogen-Aktivator-Aktivität (PAA) des Endothels der Rattenaorta. I Kongreß für Thrombose und Blutgerinnung. Schattauer Verlag (in press); Blut: 1980. 40 176 (Abstr)
    Google Scholar
  • 13 Björkerud S, Bonjers G. Endothelial integrity and viability in the aorta of the normal rabbit and rat as evaluated with dye exclusion tests and interference contrast microscopy. Atherosclerosis 1972; 15: 285-300
    CrossrefPubMedGoogle Scholar
  • 14 Gutstein WH, Farrell GA, Armellini C. Blood flow disturbance and endothelial cell injury in preatherosclerotic swine. Lab Invest 1973; 27: 134-149
    PubMedGoogle Scholar
  • 15 Reidy MA, Bowyer DE. Scanning electron microscopy of arteries. The morphology of aortic endothelium in haemodynamically stressed areas associated with branches. Atherosclerosis 1977; 26: 181-194
    CrossrefPubMedGoogle Scholar
  • 16 Wright HP. Endothelial mitosis around aortic branches in normal guinea-pigs. Nature 1968; 220: 78-79
    CrossrefPubMedGoogle Scholar
  • 17 Wright HP. Endothelial turnover. Thromb Diath haemorrh suppl 1970; 40: 79-84
    PubMedGoogle Scholar
  • 18 Wright HP. Areas of mitosis in aortic endothelium of guinea-pigs. J Path 1971; 105: 65-67
    CrossrefPubMedGoogle Scholar
  • 19 Wright HP. Mitosis patterns in aortic endothelium. Atherosclerosis 1972; 15: 93-100
    CrossrefPubMedGoogle Scholar
  • 20 Schwartz SM, Benditt EP. Cell replication in the aortic endothelium. A new method for study of the problem. Lab Invest 1973; 28: 699-707
    PubMedGoogle Scholar
  • 21 Jørgensen L, Packham MA, Rowsell HC, Mustard JF. Deposition of formed elements of blood on the intima and signs of intimal injury in the aorta of rabbits, pigs, and man. Lab Invest 1972; 27: 341-350
    PubMedGoogle Scholar
  • 22 Florentin RA, Nam SC, Lee KT, Lee KJ, Thomas WA. Increased mitotic activity in aortas of swine. Arch Path 1969; 88: 463-469
    PubMedGoogle Scholar
  • 23 Ross R, Glomset JA. Atherosclerosis and the arterial smooth muscle cell. Science 1973; 180: 1332-1339
    CrossrefPubMedGoogle Scholar
  • 24 Packham MA, Rowsell HC, Jørgensen L, Mustard JF. Localized protein accumulation in the wall of the aorta. Exper Mol Path 1967; 7: 214-232
    PubMedGoogle Scholar
  • 25 Somer JB, Schwartz CJ. Focal 3H-cholesterol uptake in the pig aorta. Atherosclerosis 1971; 13: 293-304
    CrossrefPubMedGoogle Scholar
  • 26 Bell FP, Somer JB, Craig IH, Schwartz CJ. Patterns of aortic evans blue uptake in vivo and in vitro. Atherosclerosis 1972; 16: 369-375
    CrossrefPubMedGoogle Scholar
  • 27 Bell FP, Adamson IL, Schwartz CJ. Aortic endothelial permeability to albumin: Focal and regional patterns of uptake and transmural distribution of 131I-albumin in the young pig. Exper Mol Path 1974; 20: 57-68
    PubMedGoogle Scholar
  • 28 Bell FP, Gallus AS, Schwartz CJ. Focal and regional patterns of uptake and the transmural distribution of 131I-fibrinogen in the pig aorta in vivo. Exper Mol Path 1974; 20: 281-292
    PubMedGoogle Scholar
  • 29 Caplan BA, Gerrity RG, Schwartz CJ. Endothelial cell morphology in focal areas of in vivo evans blue uptake in the young pig aorta. I Quantitative light microscopic findings. Exper Mol Path 1974; 21: 102-117
    PubMedGoogle Scholar
  • 30 Giacomelli F, Wiener J. Regional variation in the permeability of rat thoracic aorta. Amer J Path 1974; 75: 513-521
    PubMedGoogle Scholar
  • 31 Katora ME, Hollis TM. Regional variation in rat aortic endothelial surface morphology: Relationship to regional aortic permeability. Exper Mol Path 1976; 24: 23-34
    PubMedGoogle Scholar
  • 32 Fry DL. Certain chemorheologic considerations regarding the blood vascular interface with particular reference to coronary artery disease. Circulation 1969; 39 Suppl 4 38-57
    CrossrefPubMedGoogle Scholar
  • 33 Caro CG, Fitz-Gerald JM, Schroter RC. Wall shear rate in arteries and distribution of early atheroma. Thromb Diath haemorrh 1970; Suppl 40: 111-116
    PubMedGoogle Scholar
  • 34 Texon M. The hemodynamic basis of atherosclerosis. Further observations. The ostiai lesion. Bull NY Acad Med 1972; 48: 733-740
    PubMedGoogle Scholar
  • 35 Gessner FB. Hemodynamic theories of atherogenesis. Circulation Res 1973; 33: 259-265
    CrossrefPubMedGoogle Scholar
  • 36 Rodkiewicz CM. Some aspects of the arterial blood flow. University of Alberta, Edmonton: 1976
    Google Scholar
  • 37 Lindsay S, Chaikoff IL. Naturally occurring arteriosclerosis in animals: A comparison with experimentally induced lesions. In: Atherosclerosis and its origin. (Eds Sandler M, Bourne GH. Academic Press, New York: 1963. p 349
    Google Scholar
  • 38 Roberts JC, Straus R, Cooper MC. (Eds) Comparative atherosclerosis. Harper and Row, Publish, New York: 1965
    Google Scholar
  • 39 Zahor Z, Czabanova V. Experimental atherosclerosis of the heart valves in rat following a long-term atherogenic regimen. Atherosclerosis 1977; 27: 49-57
    CrossrefPubMedGoogle Scholar
  • 40 Fuchs U, Jobst M, Gepp G, Gottschild D. Arterial permeability to labeled protein. Progr Biochem Pharmacol 1977; 14: 161-163
    PubMedGoogle Scholar
  • 41 Adams CW M. J Clin Path 1973; 26 (Suppl 5) 38
    PubMed
  • 42 Ross R, Glomset J, Harker L. Response to injury and atherogenesis. Amer J Path 1977; 86: 675-684
    PubMedGoogle Scholar
  • 43 Mustard JF. Thrombosis and arterial disease. In: Venous and Arterial Thrombosis, pathogenesis, diagnosis, prevention, and therapy. (Eds. Joist JH, Sherman LA. Grune and Stratton, Inc, New York: 1979. pp 207-223
    Google Scholar
  • 44 Kadish JL. Fibrin and atherogenesis – A hypothesis. Atherosclerosis 1979; 33: 409-413
    CrossrefPubMedGoogle Scholar
  • 45 Astrup T. Pathophysiology of the fibrinolytic system and the pathogenesis of arteriosclerosis. Minerva Cardioangiologica 1974; 22: 5
    PubMedGoogle Scholar
  • 46 Pearson TA, Dillman J, Solez K, Heptinstall RH. Monoclonal characteristics of organising arterial thrombi. Significance in the origin and growth of human atherosclerotic plaques. Lancet 1979; 1: 7-11
    PubMedGoogle Scholar
  • 47 Copley AL. Fibrin(ogen), platelets and a new theory of atherogenesis. Thromb Res 1979; 14: 249-263
    CrossrefPubMedGoogle Scholar
  • 48 Reich E. Tumor-associated fibrinolysis. Federation Proc 1973; 32: 2174-2175
    PubMedGoogle Scholar
  • 49 McNicol GP, Douglas AS. The fibrinolytic enzyme system. In: Human blood coagulation, Haemostasis, and Thrombosis. Biggs R. Blackwell Scientific Publ: 1976. pp 399-435
    Google Scholar
  • 50 Blumberg PM, Robbins PW. Effect of proteases on activation of resting chick embryo fibroblasts and on cell surface proteins. Cell 1975; 6: 137-147
    CrossrefPubMedGoogle Scholar
  • 51 Lazarowitz SG, Goldberg AR, Choppin PW. Proteolytic cleavage by plasmin of the HA polypeptide of influenza virus: Host cell activation of serum plasminogen. Virology 1973; 56: 172-180
    CrossrefPubMedGoogle Scholar
  • 51a Greenberg IP, Packham MA, Guccione MA, Rand ML, Reimers HI, Mustard IF. Survival of rabbit platelets treated in vitro with chymotrypsin, plasmin, trypsin, or neuraminidase. Blood 1979; 53: 916-927
    PubMedGoogle Scholar
  • 52 Klynstra FB, Böttcher CJ F. Permeability patterns in pig aorta. Atherosclerosis 1970; 11: 451-462
    CrossrefPubMedGoogle Scholar
  • 53 Klynstra FB. On the passage-restricting role of acid mucopolysaccharides in the endothelium of pig aortas. Atherosclerosis 1974; 19: 215-220
    CrossrefPubMedGoogle Scholar
  • 54 Bray BA, Hsu KC, Wigger HJ, Le Roy EC. Association of fibrinogen and microfibrils with trophoblast basement membrane. Connect Tissue Res 1975; 3: 55-71
    CrossrefPubMedGoogle Scholar
  • 55 Martinez-Hernandez A, Fink LM, Pierce GB. Lab Invest 1976; 34: 455
    PubMed
  • 56 Reich E. Plasminogen activator: Secretion by neoplastic cells and macrophages. In: Proteases and Biological Control.. (Eds Reich E, Rifkin DB, Shaw W. ) Cold Spring Harbor Lab: 1975. 2: 333-341
    Google Scholar
  • 57 Beers WH. Follicular plasminogen and plasminogen activator and the effect of plasmin on ovarian follicle wall. Cell 1975; 6: 379-386
    CrossrefPubMedGoogle Scholar
  • 58 Beers WH, Strickland S, Reich E. Ovarian plasminogen activator: Relationship to ovulation and hormonal regulation. Cell 1975; 6: 387-394
    CrossrefPubMedGoogle Scholar
  • 59 Strickland S, Beers WH. Studies on the role of plasminogen activator in ovulation. J Biol Chem 1976; 251: 5694-5702
    PubMedGoogle Scholar
  • 60 Kucherlapati R, Tepper R, Granelli-Piperno A, Reich E. Modulation and mapping of a human plasminogen activator by cell fusion. Cell 1978; 15: 1331-1340
    CrossrefPubMedGoogle Scholar
  • 61 Ossowski L, Biegel D, Reich E. Mammary plasminogen activator: Correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue. Cell 1979; 16: 929-940
    CrossrefPubMedGoogle Scholar
  • 62 Werb Z, Mainardi CL, Vater CA, Harris ED. Endogenous activation of latent collagenase by rheumatoid synovial cells. N Engl J Med 1977; 296: 1017-1023
    CrossrefPubMedGoogle Scholar
  • 63 Sawyer PN. Effect of brinase and thrombolysin on the electrochemical nature of the cardiovascular system of experimental animals (dogs and rabbits). Thromb Res 1977; 10: 531-536
    CrossrefPubMedGoogle Scholar
  • 64 Jones R, Vesselinovitch D, Wissler RW. Ultrastructural changes in aortas of Rhesus monkeys during reversal of atherosclerotic lesions. Amer J Path 1973; 70: 88-89
    PubMedGoogle Scholar
  • 65 Weber G, Fabbrini P, Resi L, Jones R, Vesselinovitch D, Wissler RW. Regression of atherosclerotic lesions in Rhesus monkey aortas after regression diet. Atherosclerosis 1977; 26: 535-547
    CrossrefPubMedGoogle Scholar
  • 66 Ratnoff OD. Increased vascular permeability induced by human plasmin. J Exp Med 1965; 122: 905-921
    CrossrefPubMedGoogle Scholar
  • 67 Malofiejew M. The biological and pharmacological properties of some fibrinogen degradation products. Scand J Haematol 1971; 8 (suppl 13) 303-310
    PubMedGoogle Scholar
  • 68 Gerdin B, Saldeen T. Effect of fibrin degradation products on microvascular permeability. Thromb Res 1978; 13: 995-1006
    CrossrefPubMedGoogle Scholar
  • 69 Benditt EP, Benditt JM. Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Nat Acad Sci USA 1973; 70: 1753-1756
    CrossrefPubMedGoogle Scholar
  • 70 Benditt EP. Evidence for a monoclonal origin of human atherosclerotic plaques and some implications. Circulation 1974; 50: 650-652
    CrossrefPubMedGoogle Scholar
  • 71 Benditt EP. Implications of the monoclonal character of human atherosclerotic plaques. Ann NY Acad Sci 1976; 275: 96-103
    CrossrefPubMedGoogle Scholar
  • 72 Benditt EP. Implications of the monoclonal character of human atherosclerotic plaques. Amer J Path 1977; 86: 693-702
    PubMedGoogle Scholar
  • 73 Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med 1976; 295: 369-377 and 420-425
    CrossrefPubMedGoogle Scholar
  • 74 Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Nat Acad Sci USA 1974; 71: 1207-1210
    CrossrefPubMedGoogle Scholar
  • 75 Rutherford RB, Ross R. Platelet factors stimulate fibroblasts and smooth muscle cells. Quiscent in plasma serum to proliferate. J Cell Biol 1976; 69: 196-203
    CrossrefPubMedGoogle Scholar
  • 76 Harker LA, Ross R, Glomset J. Role of the platelet in atherogenesis. Ann NY Acad Sci 1976; 275: 321-329
    CrossrefPubMedGoogle Scholar
  • 77 Roensch LF, Blohm TR. Interactions of lipoproteins with cells in culture. In: Low density lipoproteins. Day C E and Levy RS. Plenum Press, New York: 1976. pp 93-110
    Google Scholar
  • 78 Kolata GB. Atherosclerotic plaques: Competing theories guide research. Science 1976; 194: 592-594
    CrossrefPubMedGoogle Scholar
  • 79 Larrieu MJ, Dray L, Ardaillou N. Biological effects of fibrinogenfibrin degradation products. Thromb Diath haemorrh 1975; 34: 686-692
    PubMedGoogle Scholar
  • 80 Niewiarowski S, Senyi AF, Gillies P. Plasmin-induced platelet aggregation and platelet release reaction. J Clin Invest 1973; 52: 1647-1659
    CrossrefPubMedGoogle Scholar
  • 81 Hanson S, Harker LA. Simultaneous 51Cr and 14C-serotonin platelet survival measurements. Thromb Haemost 1977; 38: 140
    PubMedGoogle Scholar
  • 82 Niewiarowski S, Gurewich V, Senyi AF, Mustard JF. The effect of fibrinolysis on platelet function. Thromb Diath haemorrh 1971; (Suppl 47) 99-110
    PubMedGoogle Scholar
  • 83 Joist JH. Platelets and fibrinolysis. Thromb Haemost 1977; 38: 955-961
    Article in Thieme ConnectPubMedGoogle Scholar
  • 84 Loskutoff DJ, Paul D. Intracellular plasminogen activator activity in growing and quiscent cells. J Cell Physiol 1978; 97: 9-16
    CrossrefPubMedGoogle Scholar
  • 85 Gospodarowicz D, Greenberg G, Bialecki H, Zetter BR. Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells. In Vitro 1978; 14: 85-118
    CrossrefPubMedGoogle Scholar
  • 86 Bernik MB, Oiler EP. Increased plasminogen activator (urokinase) in tissue culture after fibrin deposition. J Clin Invest 1973; 52: 823-834
    CrossrefPubMedGoogle Scholar
  • 87 Wiman B, Collen D. Molecular mechanism of physiological fibrinolysis. Nature 1978; 272: 549-550
    CrossrefPubMedGoogle Scholar
  • 88 Lipinski B, Gurewich V. α2-plasmin inhibitor deficiency. Lancet 1979; 1: 329
    PubMedGoogle Scholar
  • 89 Müllertz S. The fibrinolytic system. Scand J Haematol 1979; (Suppl 34) 15-23
    PubMedGoogle Scholar
  • 90 Chesterman CN, Allington MJ, Sharp AA. Relationship of plasminogen activator to fibrin. Nature New Biology 1972; 238: 15-17
    PubMedGoogle Scholar
  • 91 Shainoff JR, Page IH. Deposition of modified fibrinogen within the aortic intima. Atherosclerosis 1972; 16: 287-305
    CrossrefPubMedGoogle Scholar
  • 92 Smith EB, Alexander KM, Massie IB. Insoluble "fibrin" in human aortic intima. Quantitative studies on the relationship between insoluble "fibrin", soluble fibrinogen and low density lipoprotein. Atherosclerosis 1976; 23: 19-39
    CrossrefPubMedGoogle Scholar
  • 93 Smith EB. Molecular interactions in human atherosclerotic plaques. Amer J Path 1977; 86: 665-674
    PubMedGoogle Scholar
  • 93a Gordon S. Macrophage neutral proteinases and defense of the lung. Fed Proc 1977; 36: 2707-2711
    PubMedGoogle Scholar
  • 94 Chandler AB, Pope JT. Arterial thrombosis in atherogenesis. In: Blood and arterial wall in atherogenesis and arterial thrombosis. Hautvast JG A J, Hermus R J J and Van Der HaarF. Leiden, E J Brill: 1975. pp 111-118
    Google Scholar
  • 95 Smith EB, Staples EM, Dietz HS. Role of endothelium in sequestration of lipoprotein and fibrinogen in aortic lesions, thrombi, and graft pseudo-intimas. Lancet 1979; 2: 812-816
    PubMedGoogle Scholar
  • 96 Morgan AD. The pathogenesis of coronary occlusion. Oxford, Blackwell Scientific Publ: 1956. p 171
    Google Scholar
  • 97 Haust MD, Movat HZ, More RH. The role of fibrin thrombi in the genesis of the common white plaque in atherosclerosis. Circulation 1956; 14: 483
    PubMedGoogle Scholar
  • 98 Burleson RL, Ennulat N. Fibrin adherence to biologic tissues. J Surg Res 1978; 25: 523-529
    CrossrefPubMedGoogle Scholar
  • 99 Chakrabarti R, Hocking ED, Fearnley GR, Mann RD, Attwell TN, Jackson D. Fibrinolytic activity and coronary-artery disease. Lancet 1968; 1: 987-990
    PubMedGoogle Scholar
  • 100 Sikka KK, Navani H, Tiagi GK, Nigam DN. Blood coagulation and fibrinolysis in relation to coronary artery disease. Ind J Med Res 1968; 56: 411-415
    PubMedGoogle Scholar
  • 101 Peabody RA, Tsapogas MJ, Wu Kwang-Tzen, Deveraj KT, Karmody AM, Eckert C. Altered endogenous fibrinolysis and biochemical factors in atherosclerosis. Arch Surg 1974; 109: 309-313
    CrossrefPubMedGoogle Scholar
  • 102 Rosing DR, Redwood DR, Brakman P, Astrup T, Epstein SE. Impairment of the diurnal fibrinolytic response in man: Effects of aging, type IV hyperlipoproteinemia, and coronary artery disease. Circulation Res 1973; 32: 752-758
    CrossrefPubMedGoogle Scholar
  • 103 Hart HC. The biological half-life of I131-fibrinogen. Thesis. Schriks' Drukkerij N V, Asten N-Br. The Netherlands 1966
    PubMedGoogle Scholar
  • 104 D'Angelo V, Villa S, Donati MB, De Gaetano G. Defective fibrinolytic and prostacylcin-like activity in human atheromatous plaques. Thromb Haemost 1978; 39: 535-536
    Article in Thieme ConnectPubMedGoogle Scholar
  • 105 Sinzinger H, Feigl W, Silberbauer K. Prostacyclin generation in atherosclerotic arteries. Lancet 1979; 2: 442-443
    PubMedGoogle Scholar
  • 106 Sinzinger H, Silberbauer K, Feigl W, Wagner O, Winter M, Auerswald W. Prostacyclin activity is diminished in different types of morphologically controlled human atherosclerotic lesions. Thromb Haemost 1979; 42: 803-804
    Article in Thieme ConnectPubMedGoogle Scholar
  • 107 Noordhoek HegtV. Localization and distribution of fibrinolysis inhibition in the walls of human arteries and veins. Thromb Res 1977; 10: 121-135
    CrossrefPubMedGoogle Scholar
  • 108 Kwann HC, Astrup T. Fibrinolytic activity in human atherosclerotic coronary arteries. Circulation Res 1967; 21: 799-804
    CrossrefPubMedGoogle Scholar
  • 109 Sarkar N. Reduced fibrinolytic activity of atherosclerotic sera caused by an increase in low-density lipoproteins in blood. Nature 1961; 189: 929-931
    CrossrefPubMedGoogle Scholar
  • 110 Naimi S, Goldstein R, Proger S. Studies of coagulation and fibrinolysis of the arterial and venous blood in normal subjects and patients with atherosclerosis. Circulation 1963; 27: 904-918
    CrossrefPubMedGoogle Scholar
  • 111 Chakrabarti R, Fearnley GR, Hocking ED, Delitheos A, Clarke GM. Fibrinolytic activity related to age in survivors of myocardial infarction. Lancet 1966; 1: 573
    PubMedGoogle Scholar
  • 112 Loncin H, Gurian JM, Loncin ME. Blood coagulation, fibrinolysis and coronary heart disease: Observations in Malaysia. J Atheroscler Res 1968; 8: 471-482
    CrossrefPubMedGoogle Scholar
  • 113 Spöttl F, Holzknecht F, Knapp E, Steinmetz U, Braunsteiner H. A basic study on the global coagulation and fibrinolysis of hyper-lipaemic and atherosclerotic patients. Atherosclerosis 1970; 12: 427-437
    CrossrefPubMedGoogle Scholar
  • 114 Browse NL, Gray L, Jarrett PE M, Morland M. Blood and vein-wall fibrinolytic activity in health and vascular disease. Brit Med J 1977; 1: 478-481
    CrossrefPubMedGoogle Scholar
  • 115 Wilkens HJ, Back N. Fibrinolysis and risk factors of atherosclerotic disease, with special emphasis on diabetes mellitus. Circul Shock 1978; 5: 125-143
    PubMedGoogle Scholar
  • 116 Meade TW, Chakrabarti R, Haines AP, North WR S, Stirling Y. Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations. Brit Med J 1979; 1: 153-156
    CrossrefPubMedGoogle Scholar
  • 117 Naimi S, Proger S. Fibrinolytic activity and coronary artery disease. Lancet 1968; 1: 1250-1251
    PubMedGoogle Scholar
  • 118 Constantini R, Hilbe G, Spöttl F, Holzknecht F. The plasminogen activator content of the arterial wall in occlusive arterial disease. Thromb Diath haemorrh 1972; 27: 649-654
    PubMedGoogle Scholar
  • 119 Walker ID, Davidson JF, Hutton I, Lawrie TD V. Disordered "fibrinolytic potential" in coronary heart disease. Thromb Res 1977; 10: 509-520
    CrossrefPubMedGoogle Scholar
  • 120 Bielawiec M, Mysliwiec M, Perzanowski A. Combined therapy with phenformin plus stanozolol in patients with occlusive arterial disease and recurrent venous thrombosis. Third Int Conf on Synthetic fibrinolytic thrombolytic agents, Glasgow 1976; (Abstr 44). In: Progress in Chemical Fibrinolysis and Thrombolysis. Davidson JF, Rowan RM, Samama MM, Desnoyers PC. Raven Press, New York: 1978. 3: 507-512
    Google Scholar
  • 121 Bielawiec M, Mysliwiec M, Perzanowski A. Long-term enhancement of fibrinolysis in patients with arteriosclerosis and recurrent venous thrombosis. First Florence Conf on Haemostasis and Thrombosis, Florence 1977 p 181
    PubMedGoogle Scholar
  • 122 Dupuy E, Fleming AF, Caen JP. Platelet function, factor VIII, fibrinogen, and fibrinolysis in Negerians, and Europeans in relation to atheroma and thrombosis. J Clin Path 1978; 31: 1094-1101
    CrossrefPubMedGoogle Scholar
  • 123 Lancet (editorial) Oestrogens and atheroma. Lancet 1978; 2: 508-510
    PubMedGoogle Scholar