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Thromb Haemost 1980; 43(02): 127-130
DOI: 10.1055/s-0038-1650032
Original Article
Schattauer GmbH Stuttgart

Abnormal Aggregation and Increased Size of Platelets in Myeloproliferative Disorders

Sergio Cortelazzo
Divisione di Ematologia, Ospedale Generate Regionale, Vicenza, Italy
,
Tiziano Barbui
Divisione di Ematologia, Ospedale Generate Regionale, Vicenza, Italy
,
Renato Bassan
Divisione di Ematologia, Ospedale Generate Regionale, Vicenza, Italy
,
Enrico Dim
Divisione di Ematologia, Ospedale Generate Regionale, Vicenza, Italy
› Author Affiliations
Further Information

Publication History

Received 04 December 1979

Accepted 03 March 1980

Publication Date:
13 July 2018 (online)

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Summary

Platelet aggregation is frequently impaired in myeloproliferative disorders (MPD). The presence of spontaneous platelet aggregation (SPA) or alterations of the aggregation pattern after ADP, epinephrine and collagen have been a frequent feature in the series of 52 patients here presented. The occurrence of SPA was not related to the findings obtained with the aggregating agents or to the number of circulating platelets. The aggregation results did not correlate with the number of megathrombocytes.

The presence of platelet abnormalities, not completely corrected after busulfan therapy, and the increased size of platelets should aid in diagnosis of myeloproliferative disorders.

Keywords

Platelet aggregation - Myeloproliferative disorders - Platelet size - Platelet function after busulfan
 

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