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Thromb Haemost 1972; 27(02): 337-348
DOI: 10.1055/s-0038-1649372
Originalarbeiten — Original Articles — Travaux Originaux
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In Vitro and in Vivo Induction of Cryofibrinogen and “Paracoagulation” by Reptilase[*]

A.J Harder
1   Department of Medicine, Kantonsspital, University of Zurich, Switzerland
,
P.W Straub
1   Department of Medicine, Kantonsspital, University of Zurich, Switzerland
› Author Affiliations
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

Small doses of Reptilase, a snake venom enzyme which exclusively liberates fibrinopeptide A from fibrinogen, leads to formation of cryofibrinogen as well as ethanol- and protamine-precipitability of plasma both in vitro and in vivo. Precipitates obtained in vitro were shown to contain both fibrinogen and fibrin monomer. At 20° C Reptilase-treated fibrinogen solutions contained complexes with a sedimentation rate of 11-11.6 s20W, similar to those observed after thrombin. The artificial production of cryofibrinogenemia in volunteers is discussed in relation to spontaneously occurring cryofibrinogenemias in patients with intravascular coagulation.

* Presented in part at the XIII. International Congress of Hematology, Munich, August 2-8,1970


 

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